TIMM8B [The Human Chemical-Genetic Interaction Map Project]

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======= TIMM8B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TIMM8B
  * **<color #00a2e8>Official Name</color>**: translocase of inner mitochondrial membrane 8 homolog B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26521|26521]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5J9|Q9Y5J9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TIMM8B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TIMM8B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606659|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-Tim10 DDP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial intermembrane space protein transporter complex|
|chaperone-mediated protein transport|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|protein localization to mitochondrion|
|sensory perception of sound|
|sensory perception of mechanical stimulus|
|mitochondrial transport|
|protein targeting|
|mitochondrial inner membrane|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|zinc ion binding|
|sensory perception|
|intracellular protein transport|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|extracellular space|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.8|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.76|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.77|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.81|
|[[:results:exp539|42°C R08 exp539]]|1.82|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.92|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.96|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.01|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|2.06|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|2.09|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.11|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.16|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.23|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq3|COQ3]]|0.542|
|[[:human genes:c:c12orf65|C12orf65]]|0.529|
|[[:human genes:r:rpusd4|RPUSD4]]|0.522|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.521|
|[[:human genes:m:mrps34|MRPS34]]|0.516|
|[[:human genes:t:tomm40|TOMM40]]|0.513|
|[[:human genes:m:mrps5|MRPS5]]|0.511|
|[[:human genes:m:mtpap|MTPAP]]|0.507|
|[[:human genes:m:mrps6|MRPS6]]|0.505|
|[[:human genes:c:crls1|CRLS1]]|0.502|
|[[:human genes:m:mrps16|MRPS16]]|0.502|
|[[:human genes:g:gfm2|GFM2]]|0.496|
|[[:human genes:m:mrpl23|MRPL23]]|0.496|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.489|
|[[:human genes:s:sco2|SCO2]]|0.487|
|[[:human genes:y:yars2|YARS2]]|0.484|
|[[:human genes:m:mrpl21|MRPL21]]|0.481|
|[[:human genes:t:timm17a|TIMM17A]]|0.481|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.481|
|[[:human genes:d:dhx30|DHX30]]|0.479|
|[[:human genes:m:mtg2|MTG2]]|0.477|
|[[:human genes:s:slc25a26|SLC25A26]]|0.477|
|[[:human genes:v:vars2|VARS2]]|0.476|
|[[:human genes:c:coq2|COQ2]]|0.476|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.476|
|[[:human genes:c:cox16|COX16]]|0.472|
|[[:human genes:m:mrps18a|MRPS18A]]|0.471|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.471|
|[[:human genes:m:mrps14|MRPS14]]|0.468|
|[[:human genes:q:qrsl1|QRSL1]]|0.467|
|[[:human genes:m:mrpl53|MRPL53]]|0.464|
|[[:human genes:r:rpe|RPE]]|0.464|
|[[:human genes:m:mrpl47|MRPL47]]|0.462|
|[[:human genes:m:mrpl15|MRPL15]]|0.461|
|[[:human genes:c:c17orf89|C17orf89]]|0.458|
|[[:human genes:n:ndufa3|NDUFA3]]|0.455|
|[[:human genes:f:ftsj2|FTSJ2]]|0.454|
|[[:human genes:g:gfm1|GFM1]]|0.453|
|[[:human genes:p:pdss1|PDSS1]]|0.453|
|[[:human genes:m:mrp63|MRP63]]|0.452|
|[[:human genes:m:mrpl12|MRPL12]]|0.452|
|[[:human genes:s:selrc1|SELRC1]]|0.451|
|[[:human genes:p:pitrm1|PITRM1]]|0.45|
|[[:human genes:m:mrps26|MRPS26]]|0.45|
|[[:human genes:p:pars2|PARS2]]|0.45|
|[[:human genes:m:mrpl44|MRPL44]]|0.449|
|[[:human genes:f:fastkd5|FASTKD5]]|0.449|
|[[:human genes:t:taz|TAZ]]|0.447|
|[[:human genes:t:triap1|TRIAP1]]|0.447|
|[[:human genes:c:coa6|COA6]]|0.447|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.443|
|[[:human genes:s:sars2|SARS2]]|0.44|
|[[:human genes:m:mrps10|MRPS10]]|0.44|
|[[:human genes:p:pgls|PGLS]]|0.439|
|[[:human genes:o:opa1|OPA1]]|0.438|
|[[:human genes:m:mrpl45|MRPL45]]|0.435|
|[[:human genes:g:gatc|GATC]]|0.432|
|[[:human genes:f:fastkd2|FASTKD2]]|0.432|
|[[:human genes:m:mtg1|MTG1]]|0.431|
|[[:human genes:e:ears2|EARS2]]|0.43|
|[[:human genes:m:mrps11|MRPS11]]|0.428|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.428|
|[[:human genes:p:pnpt1|PNPT1]]|0.425|
|[[:human genes:t:tars2|TARS2]]|0.425|
|[[:human genes:c:coq6|COQ6]]|0.424|
|[[:human genes:d:dap3|DAP3]]|0.424|
|[[:human genes:m:mrpl36|MRPL36]]|0.423|
|[[:human genes:m:mrpl55|MRPL55]]|0.42|
|[[:human genes:t:trub2|TRUB2]]|0.42|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.42|
|[[:human genes:r:rpia|RPIA]]|0.419|
|[[:human genes:m:mrps21|MRPS21]]|0.418|
|[[:human genes:l:lars2|LARS2]]|0.418|
|[[:human genes:p:parl|PARL]]|0.416|
|[[:human genes:c:chchd4|CHCHD4]]|0.416|
|[[:human genes:r:rbfa|RBFA]]|0.414|
|[[:human genes:s:sec62|SEC62]]|0.414|
|[[:human genes:b:bcs1l|BCS1L]]|0.413|
|[[:human genes:m:mrpl22|MRPL22]]|0.413|
|[[:human genes:m:mrps22|MRPS22]]|0.413|
|[[:human genes:m:mrpl20|MRPL20]]|0.413|
|[[:human genes:n:ndufb5|NDUFB5]]|0.411|
|[[:human genes:m:mrps33|MRPS33]]|0.411|
|[[:human genes:n:ndufb11|NDUFB11]]|0.411|
|[[:human genes:a:alg8|ALG8]]|0.408|
|[[:human genes:d:dars2|DARS2]]|0.405|
|[[:human genes:m:mcat|MCAT]]|0.404|
|[[:human genes:t:trmt10a|TRMT10A]]|0.404|
|[[:human genes:i:isca2|ISCA2]]|0.403|
|[[:human genes:a:aifm1|AIFM1]]|0.403|
|[[:human genes:e:eral1|ERAL1]]|0.403|
|[[:human genes:p:pmm2|PMM2]]|0.402|
|[[:human genes:r:romo1|ROMO1]]|0.402|
|[[:human genes:t:tomm20|TOMM20]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2873
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.81 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TIMM8B Expression in NALM6 Cells: 4.81'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>