TK1 [The Human Chemical-Genetic Interaction Map Project]

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======= TK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TK1
  * **<color #00a2e8>Official Name</color>**: thymidine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7083|7083]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04183|P04183]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/188300|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates dTMP and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TK|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|thymidine kinase activity|
|pyrimidine deoxyribonucleoside metabolic process|
|thymidine metabolic process|
|deoxyribonucleoside metabolic process|
|deoxyribonucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside salvage|
|pyrimidine-containing compound salvage|
|deoxyribonucleoside monophosphate metabolic process|
|nucleoside salvage|
|pyrimidine nucleoside biosynthetic process|
|cellular metabolic compound salvage|
|pyrimidine nucleoside metabolic process|
|nucleoside biosynthetic process|
|glycosyl compound biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|pyrimidine-containing compound biosynthetic process|
|nucleoside monophosphate metabolic process|
|protein homotetramerization|
|nucleobase-containing small molecule biosynthetic process|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|DNA biosynthetic process|
|glycosyl compound metabolic process|
|protein tetramerization|
|nucleoside phosphate biosynthetic process|
|protein homooligomerization|
|nucleoside phosphate metabolic process|
|protein complex oligomerization|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|DNA metabolic process|
|zinc ion binding|
|organophosphate metabolic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|ATP binding|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.4|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.31|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.26|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.21|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.17|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.08|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.9|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-1.84|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.81|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12750
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TK1 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>