TLR1 [The Human Chemical-Genetic Interaction Map Project]

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======= TLR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TLR1
  * **<color #00a2e8>Official Name</color>**: toll like receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7096|7096]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15399|Q15399]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TLR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TLR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601194|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852). Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:21078852}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRR 4|
|TIR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|toll-like receptor 1 signaling pathway|
|detection of triacyl bacterial lipopeptide|
|Toll-like receptor 1-Toll-like receptor 2 protein complex|
|response to triacyl bacterial lipopeptide|
|cellular response to triacyl bacterial lipopeptide|
|detection of bacterial lipopeptide|
|Toll-like receptor 2 binding|
|toll-like receptor TLR1:TLR2 signaling pathway|
|detection of bacterial lipoprotein|
|response to bacterial lipopeptide|
|cellular response to bacterial lipopeptide|
|positive regulation of toll-like receptor 2 signaling pathway|
|cellular response to bacterial lipoprotein|
|response to bacterial lipoprotein|
|lipopeptide binding|
|regulation of toll-like receptor 2 signaling pathway|
|detection of molecule of bacterial origin|
|detection of bacterium|
|detection of other organism|
|positive regulation of interleukin-8 secretion|
|positive regulation of interleukin-6 biosynthetic process|
|detection of external biotic stimulus|
|positive regulation of tumor necrosis factor biosynthetic process|
|detection of biotic stimulus|
|positive regulation of toll-like receptor signaling pathway|
|regulation of interleukin-6 biosynthetic process|
|regulation of interleukin-8 secretion|
|regulation of tumor necrosis factor biosynthetic process|
|MyD88-dependent toll-like receptor signaling pathway|
|positive regulation of interleukin-8 production|
|macrophage activation|
|positive regulation of cytokine biosynthetic process|
|regulation of toll-like receptor signaling pathway|
|regulation of interleukin-8 production|
|phagocytic vesicle membrane|
|positive regulation of tumor necrosis factor production|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of interleukin-6 production|
|toll-like receptor signaling pathway|
|regulation of cytokine biosynthetic process|
|pattern recognition receptor signaling pathway|
|transmembrane signaling receptor activity|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|cellular response to molecule of bacterial origin|
|regulation of cytokine secretion|
|signaling receptor activity|
|cellular response to biotic stimulus|
|membrane raft|
|innate immune response-activating signal transduction|
|activation of innate immune response|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|response to molecule of bacterial origin|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of defense response|
|protein heterodimerization activity|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|detection of chemical stimulus|
|immune response-activating signal transduction|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|response to bacterium|
|detection of stimulus|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|positive regulation of immune response|
|leukocyte activation|
|defense response to other organism|
|Golgi apparatus|
|positive regulation of transport|
|regulation of protein localization|
|identical protein binding|
|cell activation|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|regulation of response to stress|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|membrane|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16710
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TLR1 Expression in NALM6 Cells: 3.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>