TM9SF2 [The Human Chemical-Genetic Interaction Map Project]

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======= TM9SF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TM9SF2
  * **<color #00a2e8>Official Name</color>**: transmembrane 9 superfamily member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9375|9375]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99805|Q99805]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TM9SF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TM9SF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604678|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  In the intracellular compartments, may function as a channel or small molecule transporter.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EMP70|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endosome membrane|
|endosome|
|protein localization to membrane|
|integral component of plasma membrane|
|cellular protein localization|
|cellular macromolecule localization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.54|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.51|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.24|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.86|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.73|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|-1.72|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|5.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.503|
|[[:human genes:p:pitpnb|PITPNB]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12596
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TM9SF2 Expression in NALM6 Cells: 7.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>