TMEM106A [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM106A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM106A
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 106A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=113277|113277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A25|Q96A25]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM106A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM106A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1356|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD80 biosynthetic process|
|CD86 biosynthetic process|
|tumor necrosis factor secretion|
|interleukin-6 secretion|
|tumor necrosis factor production|
|tumor necrosis factor superfamily cytokine production|
|interleukin-1 beta secretion|
|positive regulation of MHC class II biosynthetic process|
|interleukin-1 secretion|
|interleukin-6 production|
|regulation of MHC class II biosynthetic process|
|interleukin-1 beta production|
|interleukin-1 production|
|positive regulation of nitric oxide metabolic process|
|cytokine secretion|
|macrophage activation|
|positive regulation of reactive oxygen species metabolic process|
|cytokine production|
|protein secretion|
|establishment of protein localization to extracellular region|
|protein localization to extracellular region|
|peptide secretion|
|regulation of reactive oxygen species metabolic process|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|glycoprotein biosynthetic process|
|regulation of neurotransmitter levels|
|glycoprotein metabolic process|
|positive regulation of MAPK cascade|
|myeloid leukocyte activation|
|carbohydrate derivative biosynthetic process|
|regulation of MAPK cascade|
|molecular function|
|innate immune response|
|leukocyte activation|
|defense response to other organism|
|secretion by cell|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of protein modification process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|protein transport|
|peptide transport|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|immune response|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7578
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM106A Expression in NALM6 Cells: 3.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>