TMEM110 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM110 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: STIMATE
  * **<color #00a2e8>Official Name</color>**: STIM activating enhancer
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=375346|375346]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86TL2|Q86TL2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM110&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM110|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574). SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679). Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679). Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574). Contributes to the maintenance and reorganization of store- dependent ER-PM junctions (PubMed:26644574). {ECO:0000269|PubMed:26322679, ECO:0000269|PubMed:26644574}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3661|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|activation of store-operated calcium channel activity|
|positive regulation of store-operated calcium channel activity|
|cortical endoplasmic reticulum|
|endoplasmic reticulum-plasma membrane contact site|
|regulation of store-operated calcium channel activity|
|positive regulation of calcineurin-NFAT signaling cascade|
|positive regulation of calcineurin-mediated signaling|
|calcium-mediated signaling using intracellular calcium source|
|regulation of calcineurin-NFAT signaling cascade|
|regulation of calcineurin-mediated signaling|
|calcium channel regulator activity|
|positive regulation of calcium ion transmembrane transporter activity|
|positive regulation of calcium-mediated signaling|
|positive regulation of cation channel activity|
|positive regulation of calcium ion transmembrane transport|
|regulation of calcium ion transmembrane transporter activity|
|regulation of calcium-mediated signaling|
|positive regulation of ion transmembrane transporter activity|
|positive regulation of transporter activity|
|positive regulation of calcium ion transport|
|positive regulation of cation transmembrane transport|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|positive regulation of ion transmembrane transport|
|regulation of cation channel activity|
|positive regulation of transmembrane transport|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|regulation of metal ion transport|
|regulation of ion transmembrane transport|
|regulation of transmembrane transport|
|regulation of ion transport|
|endoplasmic reticulum membrane|
|positive regulation of transport|
|positive regulation of intracellular signal transduction|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9657
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM110 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>