TMEM119 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM119 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM119
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 119
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=338773|338773]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q4V9L6|Q4V9L6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM119&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM119|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618989|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of bone development|
|positive regulation of osteoblast proliferation|
|negative regulation of bone resorption|
|negative regulation of bone remodeling|
|negative regulation of myotube differentiation|
|negative regulation of tissue remodeling|
|regulation of osteoblast proliferation|
|regulation of bone development|
|replacement ossification|
|endochondral ossification|
|negative regulation of striated muscle cell differentiation|
|positive regulation of bone mineralization|
|regulation of bone resorption|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|regulation of bone remodeling|
|negative regulation of muscle cell differentiation|
|regulation of myotube differentiation|
|positive regulation of osteoblast differentiation|
|endochondral bone morphogenesis|
|regulation of tissue remodeling|
|regulation of bone mineralization|
|positive regulation of ossification|
|regulation of biomineral tissue development|
|biomineral tissue development|
|regulation of biomineralization|
|biomineralization|
|regulation of striated muscle cell differentiation|
|regulation of osteoblast differentiation|
|bone morphogenesis|
|osteoblast differentiation|
|regulation of muscle cell differentiation|
|spermatid differentiation|
|regulation of ossification|
|bone development|
|skeletal system morphogenesis|
|ossification|
|cellular process involved in reproduction in multicellular organism|
|skeletal system development|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|gamete generation|
|negative regulation of cell differentiation|
|molecular function|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.05|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-2.02|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.96|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-1.88|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.82|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2780
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM119 Expression in NALM6 Cells: 4.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>