TMEM242 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM242 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM242
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 242
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=729515|729515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NWH2|Q9NWH2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM242&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM242|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1358|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.99|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.91|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.86|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.78|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.7|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.73|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.91|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.91|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.93|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.05|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.07|
|[[:results:exp539|42°C R08 exp539]]|2.09|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|2.15|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrpl21|MRPL21]]|0.601|
|[[:human genes:s:selrc1|SELRC1]]|0.594|
|[[:human genes:a:atp5d|ATP5D]]|0.572|
|[[:human genes:b:bcs1l|BCS1L]]|0.572|
|[[:human genes:y:yars2|YARS2]]|0.572|
|[[:human genes:a:atp5b|ATP5B]]|0.568|
|[[:human genes:e:ears2|EARS2]]|0.564|
|[[:human genes:a:atp5a1|ATP5A1]]|0.561|
|[[:human genes:a:atp5c1|ATP5C1]]|0.56|
|[[:human genes:c:c17orf89|C17orf89]]|0.557|
|[[:human genes:f:fh|FH]]|0.554|
|[[:human genes:f:fastkd5|FASTKD5]]|0.553|
|[[:human genes:m:mrps5|MRPS5]]|0.551|
|[[:human genes:m:mrps34|MRPS34]]|0.551|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.549|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.549|
|[[:human genes:l:lsm10|LSM10]]|0.546|
|[[:human genes:g:gatc|GATC]]|0.542|
|[[:human genes:d:dnlz|DNLZ]]|0.542|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.538|
|[[:human genes:s:sco2|SCO2]]|0.537|
|[[:human genes:n:nars2|NARS2]]|0.536|
|[[:human genes:c:cox16|COX16]]|0.531|
|[[:human genes:t:tars2|TARS2]]|0.529|
|[[:human genes:r:rpusd4|RPUSD4]]|0.527|
|[[:human genes:d:dap3|DAP3]]|0.525|
|[[:human genes:n:ndufb5|NDUFB5]]|0.525|
|[[:human genes:s:slc25a26|SLC25A26]]|0.522|
|[[:human genes:m:mrpl23|MRPL23]]|0.517|
|[[:human genes:t:thg1l|THG1L]]|0.512|
|[[:human genes:a:atp5o|ATP5O]]|0.509|
|[[:human genes:g:gfm2|GFM2]]|0.505|
|[[:human genes:m:mrps14|MRPS14]]|0.504|
|[[:human genes:v:vars2|VARS2]]|0.503|
|[[:human genes:p:pgm3|PGM3]]|0.502|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.501|
|[[:human genes:q:qrsl1|QRSL1]]|0.501|
|[[:human genes:p:pars2|PARS2]]|0.501|
|[[:human genes:t:trmt61a|TRMT61A]]|0.499|
|[[:human genes:r:rpia|RPIA]]|0.498|
|[[:human genes:p:pdss1|PDSS1]]|0.496|
|[[:human genes:m:mrps16|MRPS16]]|0.493|
|[[:human genes:m:mrp63|MRP63]]|0.492|
|[[:human genes:d:dhrsx|DHRSX]]|0.489|
|[[:human genes:l:lars2|LARS2]]|0.486|
|[[:human genes:m:mrps2|MRPS2]]|0.485|
|[[:human genes:c:c12orf65|C12orf65]]|0.484|
|[[:human genes:m:mrps18a|MRPS18A]]|0.482|
|[[:human genes:p:ppp6c|PPP6C]]|0.482|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.481|
|[[:human genes:g:gfm1|GFM1]]|0.481|
|[[:human genes:t:triap1|TRIAP1]]|0.48|
|[[:human genes:h:hars2|HARS2]]|0.48|
|[[:human genes:r:rbfa|RBFA]]|0.478|
|[[:human genes:s:sars2|SARS2]]|0.477|
|[[:human genes:a:atp5h|ATP5H]]|0.477|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.476|
|[[:human genes:t:tefm|TEFM]]|0.475|
|[[:human genes:m:mtg1|MTG1]]|0.474|
|[[:human genes:a:atp5j|ATP5J]]|0.474|
|[[:human genes:s:slc25a19|SLC25A19]]|0.472|
|[[:human genes:m:mrpl47|MRPL47]]|0.471|
|[[:human genes:p:pmm2|PMM2]]|0.471|
|[[:human genes:p:pmvk|PMVK]]|0.47|
|[[:human genes:d:dars2|DARS2]]|0.468|
|[[:human genes:t:ten1|TEN1]]|0.468|
|[[:human genes:p:polg|POLG]]|0.466|
|[[:human genes:m:mrpl12|MRPL12]]|0.465|
|[[:human genes:g:gemin7|GEMIN7]]|0.465|
|[[:human genes:n:n6amt1|N6AMT1]]|0.464|
|[[:human genes:m:mrps6|MRPS6]]|0.462|
|[[:human genes:m:mrps21|MRPS21]]|0.461|
|[[:human genes:m:mrps26|MRPS26]]|0.46|
|[[:human genes:t:tufm|TUFM]]|0.459|
|[[:human genes:h:hccs|HCCS]]|0.457|
|[[:human genes:n:ndufa3|NDUFA3]]|0.456|
|[[:human genes:c:cox7b|COX7B]]|0.455|
|[[:human genes:m:mrps10|MRPS10]]|0.453|
|[[:human genes:o:opa1|OPA1]]|0.452|
|[[:human genes:n:ndufb11|NDUFB11]]|0.452|
|[[:human genes:m:mipep|MIPEP]]|0.452|
|[[:human genes:m:mtg2|MTG2]]|0.451|
|[[:human genes:c:c10orf2|C10orf2]]|0.447|
|[[:human genes:d:dohh|DOHH]]|0.446|
|[[:human genes:c:coa6|COA6]]|0.445|
|[[:human genes:a:atpaf2|ATPAF2]]|0.444|
|[[:human genes:p:pet112|PET112]]|0.443|
|[[:human genes:m:mrpl55|MRPL55]]|0.443|
|[[:human genes:a:alg1|ALG1]]|0.443|
|[[:human genes:p:ppcs|PPCS]]|0.442|
|[[:human genes:m:mrpl53|MRPL53]]|0.442|
|[[:human genes:r:rars2|RARS2]]|0.442|
|[[:human genes:c:chchd4|CHCHD4]]|0.442|
|[[:human genes:m:mrps9|MRPS9]]|0.442|
|[[:human genes:c:coq3|COQ3]]|0.441|
|[[:human genes:u:uap1|UAP1]]|0.441|
|[[:human genes:f:fars2|FARS2]]|0.44|
|[[:human genes:t:tpk1|TPK1]]|0.44|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.439|
|[[:human genes:a:aars2|AARS2]]|0.437|
|[[:human genes:m:mrpl20|MRPL20]]|0.436|
|[[:human genes:w:wbscr16|WBSCR16]]|0.436|
|[[:human genes:a:atp5l|ATP5L]]|0.435|
|[[:human genes:w:wars2|WARS2]]|0.434|
|[[:human genes:z:zcrb1|ZCRB1]]|0.431|
|[[:human genes:c:coa3|COA3]]|0.427|
|[[:human genes:p:prkrir|PRKRIR]]|0.426|
|[[:human genes:m:mrpl15|MRPL15]]|0.426|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.425|
|[[:human genes:a:atp5e|ATP5E]]|0.424|
|[[:human genes:p:ppcdc|PPCDC]]|0.424|
|[[:human genes:p:pet100|PET100]]|0.423|
|[[:human genes:u:uqcr10|UQCR10]]|0.423|
|[[:human genes:m:mars2|MARS2]]|0.422|
|[[:human genes:p:polg2|POLG2]]|0.422|
|[[:human genes:n:ndufb6|NDUFB6]]|0.422|
|[[:human genes:s:ssb|SSB]]|0.421|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.421|
|[[:human genes:m:mrps25|MRPS25]]|0.42|
|[[:human genes:n:ndufv1|NDUFV1]]|0.42|
|[[:human genes:u:uqcc2|UQCC2]]|0.419|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.418|
|[[:human genes:t:trmt10a|TRMT10A]]|0.418|
|[[:human genes:a:atxn10|ATXN10]]|0.416|
|[[:human genes:p:pdcd5|PDCD5]]|0.416|
|[[:human genes:m:mrps11|MRPS11]]|0.415|
|[[:human genes:f:ftsj2|FTSJ2]]|0.415|
|[[:human genes:s:slc25a3|SLC25A3]]|0.415|
|[[:human genes:e:elac2|ELAC2]]|0.415|
|[[:human genes:t:tamm41|TAMM41]]|0.414|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.414|
|[[:human genes:d:dhx30|DHX30]]|0.414|
|[[:human genes:a:adsl|ADSL]]|0.414|
|[[:human genes:r:rptor|RPTOR]]|0.412|
|[[:human genes:r:rpp21|RPP21]]|0.412|
|[[:human genes:v:vezt|VEZT]]|0.411|
|[[:human genes:m:mtif3|MTIF3]]|0.411|
|[[:human genes:g:g6pd|G6PD]]|0.411|
|[[:human genes:z:zrsr2|ZRSR2]]|0.411|
|[[:human genes:i:iba57|IBA57]]|0.41|
|[[:human genes:c:cox11|COX11]]|0.407|
|[[:human genes:a:atp5sl|ATP5SL]]|0.406|
|[[:human genes:c:cox15|COX15]]|0.406|
|[[:human genes:c:cox5a|COX5A]]|0.405|
|[[:human genes:g:gemin8|GEMIN8]]|0.404|
|[[:human genes:e:ecsit|ECSIT]]|0.401|
|[[:human genes:m:mbtps2|MBTPS2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6425
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM242 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>