TMEM30B [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM30B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM30B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 30B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=161291|161291]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3MIR4|Q3MIR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM30B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM30B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611029|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269|PubMed:20961850, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDC50|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|aminophospholipid flippase activity|
|aminophospholipid translocation|
|aminophospholipid transport|
|positive regulation of protein exit from endoplasmic reticulum|
|ATPase-coupled intramembrane lipid transporter activity|
|regulation of protein exit from endoplasmic reticulum|
|phospholipid translocation|
|lipid translocation|
|regulation of membrane lipid distribution|
|phospholipid transport|
|organophosphate ester transport|
|positive regulation of intracellular protein transport|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|lipid transport|
|lipid localization|
|positive regulation of cellular protein localization|
|regulation of intracellular transport|
|positive regulation of protein transport|
|organic anion transport|
|positive regulation of establishment of protein localization|
|regulation of cellular protein localization|
|anion transport|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|membrane organization|
|regulation of cellular localization|
|Golgi apparatus|
|positive regulation of transport|
|endoplasmic reticulum|
|regulation of protein localization|
|ion transport|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6783
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM30B Expression in NALM6 Cells: -3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>