TMEM38B [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM38B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM38B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 38B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55151|55151]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVV0|Q9NVV0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM38B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM38B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611236|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q9DAV9}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TRIC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|secretion by lung epithelial cell involved in lung growth|
|extracellular matrix constituent secretion|
|lung growth|
|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|release of sequestered calcium ion into cytosol by endoplasmic reticulum|
|cellular response to caffeine|
|cellular response to purine-containing compound|
|sarcoplasmic reticulum calcium ion transport|
|response to diuretic|
|response to caffeine|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|lung epithelial cell differentiation|
|lung cell differentiation|
|regulation of cardiac muscle contraction by calcium ion signaling|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|potassium channel activity|
|lung epithelium development|
|sarcoplasmic reticulum membrane|
|cellular response to alkaloid|
|lung alveolus development|
|bone mineralization|
|endoplasmic reticulum organization|
|release of sequestered calcium ion into cytosol|
|negative regulation of sequestering of calcium ion|
|calcium ion transmembrane import into cytosol|
|calcium ion transport into cytosol|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|cytosolic calcium ion transport|
|regulation of striated muscle contraction|
|biomineral tissue development|
|biomineralization|
|organ growth|
|regulation of calcium ion transport into cytosol|
|response to alkaloid|
|regulation of sequestering of calcium ion|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|response to purine-containing compound|
|potassium ion transmembrane transport|
|regulation of muscle contraction|
|potassium ion transport|
|lung development|
|respiratory tube development|
|cellular response to xenobiotic stimulus|
|respiratory system development|
|calcium ion transmembrane transport|
|bone development|
|regulation of muscle system process|
|nuclear membrane|
|regulation of heart contraction|
|phospholipid biosynthetic process|
|regulation of calcium ion transport|
|calcium ion transport|
|ossification|
|positive regulation of cytosolic calcium ion concentration|
|regulation of blood circulation|
|divalent metal ion transport|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|extracellular matrix organization|
|phospholipid metabolic process|
|extracellular structure organization|
|regulation of metal ion transport|
|developmental growth|
|growth|
|monovalent inorganic cation transport|
|cellular response to drug|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|skeletal system development|
|organophosphate biosynthetic process|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|lipid biosynthetic process|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|epithelial cell differentiation|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|tube development|
|organophosphate metabolic process|
|cellular homeostasis|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|cellular lipid metabolic process|
|response to organonitrogen compound|
|secretion by cell|
|response to drug|
|export from cell|
|response to nitrogen compound|
|chemical homeostasis|
|epithelium development|
|secretion|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|response to endogenous stimulus|
|homeostatic process|
|intracellular signal transduction|
|tissue development|
|establishment of localization in cell|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|1.86|
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13422
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM38B Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>