TMSB4Y [The Human Chemical-Genetic Interaction Map Project]

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======= TMSB4Y =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMSB4Y
  * **<color #00a2e8>Official Name</color>**: thymosin beta 4 Y-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9087|9087]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14604|O14604]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMSB4Y&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMSB4Y|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/400017|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thymosin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of actin monomers|
|actin monomer binding|
|negative regulation of actin filament polymerization|
|negative regulation of protein polymerization|
|maintenance of protein location in cell|
|maintenance of location in cell|
|maintenance of protein location|
|negative regulation of protein complex assembly|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|maintenance of location|
|regulation of actin filament polymerization|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of protein polymerization|
|actin filament organization|
|regulation of actin filament organization|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|actin cytoskeleton organization|
|regulation of anatomical structure size|
|regulation of cytoskeleton organization|
|actin filament-based process|
|negative regulation of cellular component organization|
|regulation of cell migration|
|regulation of cell motility|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|regulation of cellular component movement|
|cytoskeleton organization|
|regulation of organelle organization|
|cellular protein localization|
|cellular macromolecule localization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.79|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.81|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.9|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.91|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17232
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMSB4Y Expression in NALM6 Cells: 4.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>