TNFRSF11B [The Human Chemical-Genetic Interaction Map Project]

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======= TNFRSF11B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFRSF11B
  * **<color #00a2e8>Official Name</color>**: TNF receptor superfamily member 11b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4982|4982]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00300|O00300]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFRSF11B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFRSF11B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602643|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:22664871, ECO:0000269|PubMed:9168977}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNFR c6|
|Death|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of odontogenesis of dentin-containing tooth|
|negative regulation of odontogenesis|
|negative regulation of bone resorption|
|regulation of odontogenesis of dentin-containing tooth|
|negative regulation of bone remodeling|
|negative regulation of tissue remodeling|
|response to magnesium ion|
|regulation of odontogenesis|
|response to arsenic-containing substance|
|negative regulation of animal organ morphogenesis|
|regulation of bone resorption|
|regulation of bone remodeling|
|regulation of tissue remodeling|
|response to estrogen|
|tumor necrosis factor-mediated signaling pathway|
|cytokine activity|
|signaling receptor activity|
|response to nutrient|
|extracellular matrix|
|cellular response to tumor necrosis factor|
|regulation of animal organ morphogenesis|
|response to tumor necrosis factor|
|extracellular matrix organization|
|response to metal ion|
|extracellular structure organization|
|skeletal system development|
|response to nutrient levels|
|response to extracellular stimulus|
|response to inorganic substance|
|cytokine-mediated signaling pathway|
|apoptotic process|
|negative regulation of developmental process|
|cellular response to cytokine stimulus|
|response to drug|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|response to cytokine|
|negative regulation of multicellular organismal process|
|extracellular space|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.76|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.73|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16917
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFRSF11B Expression in NALM6 Cells: -0.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>