TNFSF12 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFSF12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF12
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8742|8742]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43508|O43508]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602695|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. {ECO:0000269|PubMed:10085077, ECO:0000269|PubMed:23667509}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tumor necrosis factor receptor binding|
|positive regulation of extrinsic apoptotic signaling pathway|
|endothelial cell migration|
|epithelial cell migration|
|epithelium migration|
|tissue migration|
|positive regulation of endothelial cell proliferation|
|extrinsic apoptotic signaling pathway|
|tumor necrosis factor-mediated signaling pathway|
|regulation of endothelial cell proliferation|
|regulation of extrinsic apoptotic signaling pathway|
|positive regulation of angiogenesis|
|ameboidal-type cell migration|
|cytokine activity|
|positive regulation of apoptotic signaling pathway|
|positive regulation of vasculature development|
|positive regulation of epithelial cell proliferation|
|positive regulation of protein catabolic process|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|signaling receptor binding|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|blood vessel morphogenesis|
|positive regulation of catabolic process|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|tube development|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|apoptotic process|
|cell migration|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|cell death|
|response to cytokine|
|locomotion|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|extracellular space|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-2.13|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.87|
|[[:results:exp331|A-769662 20μM R07 exp331]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3786
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF12 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>