TNFSF13B [The Human Chemical-Genetic Interaction Map Project]

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======= TNFSF13B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF13B
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 13b
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10673|10673]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y275|Q9Y275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF13B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF13B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603969|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}. Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN- gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of germinal center formation|
|B cell costimulation|
|immunoglobulin secretion|
|regulation of germinal center formation|
|B cell homeostasis|
|tumor necrosis factor receptor binding|
|positive regulation of B cell proliferation|
|lymphocyte homeostasis|
|T cell costimulation|
|lymphocyte costimulation|
|regulation of B cell proliferation|
|leukocyte homeostasis|
|positive regulation of T cell proliferation|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|tumor necrosis factor-mediated signaling pathway|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|regulation of T cell proliferation|
|immunoglobulin production|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of adaptive immune response|
|protein localization to extracellular region|
|positive regulation of B cell activation|
|peptide secretion|
|cytokine activity|
|production of molecular mediator of immune response|
|homeostasis of number of cells|
|positive regulation of T cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|cellular response to tumor necrosis factor|
|positive regulation of cell-cell adhesion|
|response to tumor necrosis factor|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|signaling receptor binding|
|positive regulation of lymphocyte activation|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of lymphocyte activation|
|regulation of leukocyte activation|
|regulation of cell activation|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|perinuclear region of cytoplasm|
|positive regulation of immune response|
|positive regulation of cell population proliferation|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of developmental process|
|protein transport|
|peptide transport|
|amide transport|
|extracellular space|
|establishment of protein localization|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|nitrogen compound transport|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.75|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11493
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.25 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF13B Expression in NALM6 Cells: 1.25'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>