TNKS [The Human Chemical-Genetic Interaction Map Project]

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======= TNKS =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNKS
  * **<color #00a2e8>Official Name</color>**: tankyrase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8658|8658]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95271|O95271]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNKS&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNKS|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603303|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. {ECO:0000269|PubMed:10988299, ECO:0000269|PubMed:11739745, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:19759537, ECO:0000269|PubMed:21478859, ECO:0000269|PubMed:22864114, ECO:0000269|PubMed:23622245}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SAM 1|
|PARP|
|SAM 2|
|Ank 2|
|Ank|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of maintenance of mitotic sister chromatid cohesion, telomeric|
|negative regulation of telomeric DNA binding|
|negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric|
|negative regulation of maintenance of sister chromatid cohesion|
|negative regulation of maintenance of mitotic sister chromatid cohesion|
|regulation of telomeric DNA binding|
|negative regulation of sister chromatid cohesion|
|regulation of maintenance of mitotic sister chromatid cohesion|
|regulation of maintenance of sister chromatid cohesion|
|protein poly-ADP-ribosylation|
|protein auto-ADP-ribosylation|
|protein localization to chromosome, telomeric region|
|protein ADP-ribosylase activity|
|positive regulation of telomere capping|
|pericentriolar material|
|regulation of sister chromatid cohesion|
|regulation of telomere capping|
|negative regulation of telomere maintenance via telomere lengthening|
|mitotic spindle pole|
|NAD+ ADP-ribosyltransferase activity|
|negative regulation of mitotic sister chromatid segregation|
|protein ADP-ribosylation|
|negative regulation of sister chromatid segregation|
|negative regulation of chromosome segregation|
|positive regulation of telomere maintenance via telomerase|
|positive regulation of telomerase activity|
|positive regulation of telomere maintenance via telomere lengthening|
|negative regulation of telomere maintenance|
|negative regulation of mitotic nuclear division|
|negative regulation of nuclear division|
|positive regulation of telomere maintenance|
|chromosome, telomeric region|
|regulation of telomerase activity|
|regulation of telomere maintenance via telomerase|
|negative regulation of DNA binding|
|regulation of telomere maintenance via telomere lengthening|
|protein localization to chromosome|
|cellular response to nutrient|
|positive regulation of DNA biosynthetic process|
|regulation of mitotic sister chromatid segregation|
|nuclear pore|
|mitotic spindle organization|
|regulation of sister chromatid segregation|
|regulation of telomere maintenance|
|peptidyl-threonine phosphorylation|
|peptidyl-threonine modification|
|spindle assembly|
|regulation of chromosome segregation|
|microtubule cytoskeleton organization involved in mitosis|
|nuclear chromosome, telomeric region|
|regulation of DNA biosynthetic process|
|negative regulation of DNA metabolic process|
|regulation of DNA binding|
|histone binding|
|negative regulation of chromosome organization|
|positive regulation of canonical Wnt signaling pathway|
|mRNA transport|
|spindle organization|
|regulation of mitotic nuclear division|
|negative regulation of binding|
|positive regulation of chromosome organization|
|peptidyl-serine phosphorylation|
|positive regulation of Wnt signaling pathway|
|RNA transport|
|regulation of nuclear division|
|nucleic acid transport|
|positive regulation of DNA metabolic process|
|establishment of RNA localization|
|peptidyl-serine modification|
|response to nutrient|
|RNA localization|
|cellular response to nutrient levels|
|nuclear membrane|
|nucleobase-containing compound transport|
|cellular response to extracellular stimulus|
|regulation of canonical Wnt signaling pathway|
|nuclear body|
|protein polyubiquitination|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|cellular response to external stimulus|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|regulation of Wnt signaling pathway|
|negative regulation of organelle organization|
|regulation of binding|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|microtubule cytoskeleton organization|
|cell division|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|microtubule-based process|
|mitotic cell cycle|
|protein ubiquitination|
|negative regulation of cellular component organization|
|protein localization to organelle|
|regulation of cell cycle process|
|organelle assembly|
|protein modification by small protein conjugation|
|zinc ion binding|
|peptidyl-amino acid modification|
|protein phosphorylation|
|regulation of transferase activity|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|cytoskeleton organization|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|phosphorylation|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|protein transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.48|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.83|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-1.75|
|[[:results:exp149|SB203580 25μM R03 exp149]]|-1.73|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.7|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.7|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14248
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNKS Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>