TNNC1 [The Human Chemical-Genetic Interaction Map Project]

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======= TNNC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNC1
  * **<color #00a2e8>Official Name</color>**: troponin C1, slow skeletal and cardiac type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7134|7134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63316|P63316]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191040|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|efhand|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of muscle filament sliding speed|
|diaphragm contraction|
|involuntary skeletal muscle contraction|
|cardiac Troponin complex|
|regulation of muscle filament sliding|
|troponin T binding|
|troponin I binding|
|transition between fast and slow fiber|
|troponin complex|
|respiratory system process|
|regulation of skeletal muscle adaptation|
|skeletal muscle contraction|
|muscle filament sliding|
|actin-myosin filament sliding|
|respiratory gaseous exchange by respiratory system|
|regulation of actin filament-based movement|
|musculoskeletal movement|
|multicellular organismal movement|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|calcium-dependent protein binding|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|cardiac muscle contraction|
|muscle tissue morphogenesis|
|regulation of ATPase activity|
|regulation of muscle adaptation|
|muscle organ morphogenesis|
|heart contraction|
|actin-mediated cell contraction|
|heart process|
|striated muscle contraction|
|actin filament-based movement|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|actin filament binding|
|regulation of muscle system process|
|muscle contraction|
|heart morphogenesis|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|regulation of intracellular transport|
|response to metal ion|
|regulation of actin filament-based process|
|blood circulation|
|circulatory system process|
|muscle structure development|
|heart development|
|response to inorganic substance|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|calcium ion binding|
|circulatory system development|
|protein homodimerization activity|
|regulation of cellular localization|
|animal organ morphogenesis|
|regulation of cellular component movement|
|regulation of hydrolase activity|
|movement of cell or subcellular component|
|tissue development|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-1.96|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.74|
|[[:results:exp362|GSK-J4 1μM R07 exp362]]|1.83|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.88|
|[[:results:exp372|Ibrutinib 1μM R07 exp372]]|2.07|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|2.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11859
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNC1 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>