TNNI1 [The Human Chemical-Genetic Interaction Map Project]

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======= TNNI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNI1
  * **<color #00a2e8>Official Name</color>**: troponin I1, slow skeletal type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7135|7135]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P19237|P19237]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191042|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Troponin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transition between fast and slow fiber|
|troponin complex|
|regulation of skeletal muscle adaptation|
|muscle filament sliding|
|actin-myosin filament sliding|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|cardiac muscle tissue morphogenesis|
|cardiac ventricle morphogenesis|
|muscle tissue morphogenesis|
|regulation of muscle adaptation|
|muscle organ morphogenesis|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|actin filament-based movement|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|cardiac chamber development|
|regulation of muscle system process|
|muscle contraction|
|heart morphogenesis|
|actin binding|
|striated muscle tissue development|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|muscle structure development|
|heart development|
|tissue morphogenesis|
|actin filament-based process|
|regulation of system process|
|circulatory system development|
|animal organ morphogenesis|
|movement of cell or subcellular component|
|tissue development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8573
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNI1 Expression in NALM6 Cells: 1.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>