TNNT3 [The Human Chemical-Genetic Interaction Map Project]

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======= TNNT3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNNT3
  * **<color #00a2e8>Official Name</color>**: troponin T3, fast skeletal type
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7140|7140]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P45378|P45378]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNNT3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNNT3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600692|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Troponin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent ATPase activity|
|troponin C binding|
|troponin I binding|
|troponin complex|
|tropomyosin binding|
|skeletal muscle contraction|
|muscle filament sliding|
|actin-myosin filament sliding|
|multicellular organismal movement|
|musculoskeletal movement|
|sarcomere organization|
|calcium-dependent protein binding|
|myofibril assembly|
|cardiac muscle contraction|
|regulation of ATPase activity|
|heart contraction|
|actin-mediated cell contraction|
|regulation of striated muscle contraction|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|actin filament-based movement|
|actomyosin structure organization|
|striated muscle cell development|
|muscle cell development|
|regulation of muscle contraction|
|striated muscle cell differentiation|
|regulation of muscle system process|
|muscle cell differentiation|
|muscle contraction|
|actin binding|
|muscle system process|
|blood circulation|
|circulatory system process|
|supramolecular fiber organization|
|muscle structure development|
|actin cytoskeleton organization|
|actin filament-based process|
|regulation of system process|
|calcium ion binding|
|organelle assembly|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cytoskeleton organization|
|regulation of hydrolase activity|
|movement of cell or subcellular component|
|cell development|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.91|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.82|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-1.81|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.78|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.77|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.72|
|[[:results:exp41|BI-2536 0.001μM R01 exp41]]|1.71|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNNT3 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>