TNPO3 [The Human Chemical-Genetic Interaction Map Project]

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======= TNPO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNPO3
  * **<color #00a2e8>Official Name</color>**: transportin 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23534|23534]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5L0|Q9Y5L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNPO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNPO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HIV-1 infection, apparently through interaction with the HIV-1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins RBM4, SFRS1 and SFRS2, by recognizing phosphorylated RS domains. {ECO:0000269|PubMed:10366588, ECO:0000269|PubMed:10713112, ECO:0000269|PubMed:11517331, ECO:0000269|PubMed:12628928}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Xpo1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear import signal receptor activity|
|protein import into nucleus|
|import into nucleus|
|protein import|
|protein localization to nucleus|
|nucleocytoplasmic transport|
|nuclear transport|
|establishment of protein localization to organelle|
|intracellular membrane-bounded organelle|
|protein localization to organelle|
|intracellular protein transport|
|identical protein binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.86|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.55|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.12|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.94|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.88|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.87|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.83|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|-1.82|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|1.71|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.76|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.82|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.83|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|2.38|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|2.49|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:z:znf541|ZNF541]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 703/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|27/28|
|blood|25/28|
|bone|24/26|
|breast|30/33|
|central nervous system|53/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|18/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|13/16|
|ovary|26/26|
|pancreas|22/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 412
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNPO3 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>