TOM1L1 [The Human Chemical-Genetic Interaction Map Project]

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======= TOM1L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TOM1L1
  * **<color #00a2e8>Official Name</color>**: target of myb1 like 1 membrane trafficking protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10040|10040]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75674|O75674]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TOM1L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TOM1L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604701|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GAT|
|VHS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|positive regulation of protein autophosphorylation|
|protein kinase activator activity|
|Golgi stack|
|clathrin binding|
|negative regulation of mitotic nuclear division|
|regulation of protein autophosphorylation|
|negative regulation of nuclear division|
|ubiquitin binding|
|regulation of DNA biosynthetic process|
|SH3 domain binding|
|regulation of mitotic nuclear division|
|regulation of nuclear division|
|endosome membrane|
|lysosome|
|endosome|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|activation of protein kinase activity|
|regulation of DNA metabolic process|
|negative regulation of organelle organization|
|protein kinase binding|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|modification-dependent macromolecule catabolic process|
|negative regulation of cell cycle|
|positive regulation of kinase activity|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|positive regulation of transferase activity|
|protein catabolic process|
|negative regulation of cellular component organization|
|regulation of cell cycle process|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|intracellular protein transport|
|positive regulation of protein phosphorylation|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|regulation of cell cycle|
|positive regulation of protein modification process|
|proteolysis|
|regulation of organelle organization|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-1.74|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.7|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10215
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TOM1L1 Expression in NALM6 Cells: 1.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>