TP53INP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TP53INP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP53INP1
  * **<color #00a2e8>Official Name</color>**: tumor protein p53 inducible nuclear protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=94241|94241]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96A56|Q96A56]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP53INP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP53INP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:22421968, ECO:0000269|PubMed:22470510}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to methyl methanesulfonate|
|response to methyl methanesulfonate|
|negative regulation of myofibroblast differentiation|
|regulation of myofibroblast differentiation|
|autophagic cell death|
|cellular response to hydroperoxide|
|cellular response to ethanol|
|antioxidant activity|
|response to hydroperoxide|
|negative regulation of fibroblast proliferation|
|autophagosome assembly|
|autophagosome organization|
|autophagosome|
|regulation of fibroblast proliferation|
|cellular response to UV|
|cellular response to alcohol|
|cellular oxidant detoxification|
|PML body|
|cellular detoxification|
|response to heat|
|cellular response to light stimulus|
|cellular response to antibiotic|
|positive regulation of autophagy|
|response to ethanol|
|detoxification|
|vacuole organization|
|response to UV|
|cell cycle arrest|
|macroautophagy|
|cellular response to radiation|
|response to temperature stimulus|
|regulation of signal transduction by p53 class mediator|
|cellular response to toxic substance|
|response to alcohol|
|cellular response to oxidative stress|
|cytoplasmic vesicle|
|negative regulation of cell migration|
|process utilizing autophagic mechanism|
|autophagy|
|negative regulation of cell motility|
|response to antibiotic|
|response to light stimulus|
|negative regulation of cellular component movement|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|negative regulation of locomotion|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|response to oxidative stress|
|cellular response to drug|
|positive regulation of catabolic process|
|response to radiation|
|response to toxic substance|
|negative regulation of cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|positive regulation of cell death|
|negative regulation of cell differentiation|
|organelle assembly|
|regulation of cellular catabolic process|
|regulation of cell migration|
|regulation of cell motility|
|apoptotic process|
|negative regulation of developmental process|
|regulation of locomotion|
|regulation of catabolic process|
|regulation of cellular component movement|
|cell cycle process|
|response to drug|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|response to abiotic stimulus|
|regulation of cell cycle|
|cell cycle|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of cell death|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp393|Resminostat 0.5μM R07 exp393]]|2.05|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19029
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP53INP1 Expression in NALM6 Cells: 3.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>