TP53TG3C [The Human Chemical-Genetic Interaction Map Project]

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======= TP53TG3C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TP53TG3C
  * **<color #00a2e8>Official Name</color>**: TP53 target 3C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=653550|653550]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULZ0|Q9ULZ0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TP53TG3C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TP53TG3C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a significant role in p53/TP53-mediating signaling pathway. {ECO:0000269|PubMed:10534768}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.88|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.72|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.71|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.77|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.548|
|[[:human genes:c:chd4|CHD4]]|0.536|
|[[:human genes:p:psmb4|PSMB4]]|0.52|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.517|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.516|
|[[:human genes:s:slc6a17|SLC6A17]]|0.515|
|[[:human genes:k:kctd17|KCTD17]]|0.514|
|[[:human genes:m:mt1e|MT1E]]|0.512|
|[[:human genes:p:psmd3|PSMD3]]|0.507|
|[[:human genes:n:npipb5|NPIPB5]]|0.507|
|[[:human genes:s:slc4a1|SLC4A1]]|0.506|
|[[:human genes:d:ddtl|DDTL]]|0.501|
|[[:human genes:t:twistnb|TWISTNB]]|0.501|
|[[:human genes:m:mfsd12|MFSD12]]|0.5|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.494|
|[[:human genes:i:ik|IK]]|0.488|
|[[:human genes:c:cactin|CACTIN]]|0.487|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.484|
|[[:human genes:a:atxn1|ATXN1]]|0.484|
|[[:human genes:c:col2a1|COL2A1]]|0.483|
|[[:human genes:c:ctage4|CTAGE4]]|0.48|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.48|
|[[:human genes:n:nupl1|NUPL1]]|0.477|
|[[:human genes:s:supt5h|SUPT5H]]|0.475|
|[[:human genes:c:cbwd3|CBWD3]]|0.475|
|[[:human genes:r:rps19|RPS19]]|0.474|
|[[:human genes:p:psmb2|PSMB2]]|0.472|
|[[:human genes:s:sap30bp|SAP30BP]]|0.472|
|[[:human genes:a:ankle1|ANKLE1]]|0.471|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.47|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.468|
|[[:human genes:a:aamp|AAMP]]|0.468|
|[[:human genes:g:golga6a|GOLGA6A]]|0.467|
|[[:human genes:g:golga6l6|GOLGA6L6]]|0.467|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.467|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.466|
|[[:human genes:p:polr2d|POLR2D]]|0.466|
|[[:human genes:g:golga8o|GOLGA8O]]|0.465|
|[[:human genes:f:foxd4l2|FOXD4L2]]|0.462|
|[[:human genes:d:dhx38|DHX38]]|0.462|
|[[:human genes:c:copa|COPA]]|0.461|
|[[:human genes:c:copg1|COPG1]]|0.46|
|[[:human genes:d:ddt|DDT]]|0.457|
|[[:human genes:h:hivep3|HIVEP3]]|0.456|
|[[:human genes:d:dock6|DOCK6]]|0.455|
|[[:human genes:a:aatf|AATF]]|0.455|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.454|
|[[:human genes:p:pbxip1|PBXIP1]]|0.454|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.453|
|[[:human genes:f:fam160a1|FAM160A1]]|0.452|
|[[:human genes:c:chmp4b|CHMP4B]]|0.452|
|[[:human genes:o:osbp|OSBP]]|0.451|
|[[:human genes:t:ticrr|TICRR]]|0.451|
|[[:human genes:u:upf1|UPF1]]|0.451|
|[[:human genes:m:med15|MED15]]|0.449|
|[[:human genes:k:krt78|KRT78]]|0.449|
|[[:human genes:e:exosc6|EXOSC6]]|0.449|
|[[:human genes:r:rps12|RPS12]]|0.445|
|[[:human genes:u:utp3|UTP3]]|0.445|
|[[:human genes:a:acsf2|ACSF2]]|0.443|
|[[:human genes:n:nol10|NOL10]]|0.442|
|[[:human genes:i:igfn1|IGFN1]]|0.442|
|[[:human genes:n:nup205|NUP205]]|0.441|
|[[:human genes:t:tfip11|TFIP11]]|0.441|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.44|
|[[:human genes:p:pan3|PAN3]]|0.44|
|[[:human genes:c:ctage9|CTAGE9]]|0.44|
|[[:human genes:e:exosc5|EXOSC5]]|0.44|
|[[:human genes:p:pan2|PAN2]]|0.439|
|[[:human genes:c:cbwd5|CBWD5]]|0.438|
|[[:human genes:n:nsf|NSF]]|0.438|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.438|
|[[:human genes:s:slc5a5|SLC5A5]]|0.438|
|[[:human genes:p:psmc2|PSMC2]]|0.437|
|[[:human genes:o:orc6|ORC6]]|0.437|
|[[:human genes:c:cep192|CEP192]]|0.437|
|[[:human genes:o:orc1|ORC1]]|0.436|
|[[:human genes:r:rpl6|RPL6]]|0.436|
|[[:human genes:v:vps28|VPS28]]|0.435|
|[[:human genes:r:rpl34|RPL34]]|0.435|
|[[:human genes:w:wdr75|WDR75]]|0.435|
|[[:human genes:r:rbbp5|RBBP5]]|0.434|
|[[:human genes:f:fcn2|FCN2]]|0.434|
|[[:human genes:t:tsg101|TSG101]]|0.433|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.433|
|[[:human genes:p:polr2j3|POLR2J3]]|0.433|
|[[:human genes:p:psmd2|PSMD2]]|0.433|
|[[:human genes:c:cdh24|CDH24]]|0.433|
|[[:human genes:l:lrr1|LRR1]]|0.432|
|[[:human genes:p:psma6|PSMA6]]|0.431|
|[[:human genes:c:cbwd6|CBWD6]]|0.431|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.431|
|[[:human genes:e:egr2|EGR2]]|0.429|
|[[:human genes:z:zfand5|ZFAND5]]|0.427|
|[[:human genes:a:aqr|AQR]]|0.427|
|[[:human genes:a:aldh1b1|ALDH1B1]]|0.427|
|[[:human genes:s:supt6h|SUPT6H]]|0.426|
|[[:human genes:z:znf830|ZNF830]]|0.426|
|[[:human genes:p:pola1|POLA1]]|0.425|
|[[:human genes:e:exosc8|EXOSC8]]|0.425|
|[[:human genes:s:sf3a3|SF3A3]]|0.425|
|[[:human genes:n:nol9|NOL9]]|0.423|
|[[:human genes:p:pole|POLE]]|0.423|
|[[:human genes:v:vasn|VASN]]|0.422|
|[[:human genes:c:copb1|COPB1]]|0.422|
|[[:human genes:r:rrp15|RRP15]]|0.422|
|[[:human genes:g:gar1|GAR1]]|0.421|
|[[:human genes:r:rnf113a|RNF113A]]|0.421|
|[[:human genes:h:hinfp|HINFP]]|0.42|
|[[:human genes:p:psma7|PSMA7]]|0.419|
|[[:human genes:n:nup160|NUP160]]|0.419|
|[[:human genes:r:rplp0|RPLP0]]|0.418|
|[[:human genes:o:ogfr|OGFR]]|0.418|
|[[:human genes:c:c14orf93|C14orf93]]|0.418|
|[[:human genes:s:smtn|SMTN]]|0.417|
|[[:human genes:c:ccdc116|CCDC116]]|0.417|
|[[:human genes:r:rpl35|RPL35]]|0.417|
|[[:human genes:s:sf3a2|SF3A2]]|0.417|
|[[:human genes:m:myh7b|MYH7B]]|0.417|
|[[:human genes:a:atp6ap2|ATP6AP2]]|0.417|
|[[:human genes:l:lad1|LAD1]]|0.416|
|[[:human genes:v:vps54|VPS54]]|0.415|
|[[:human genes:p:ppp1r13l|PPP1R13L]]|0.415|
|[[:human genes:r:rnpc3|RNPC3]]|0.414|
|[[:human genes:s:syt9|SYT9]]|0.414|
|[[:human genes:n:narfl|NARFL]]|0.414|
|[[:human genes:p:pwp2|PWP2]]|0.414|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.414|
|[[:human genes:s:snrpa1|SNRPA1]]|0.414|
|[[:human genes:r:rps7|RPS7]]|0.413|
|[[:human genes:e:eif4a3|EIF4A3]]|0.412|
|[[:human genes:a:akt1s1|AKT1S1]]|0.412|
|[[:human genes:n:napa|NAPA]]|0.412|
|[[:human genes:h:hnrnpa1|HNRNPA1]]|0.411|
|[[:human genes:p:psmb3|PSMB3]]|0.411|
|[[:human genes:s:sec13|SEC13]]|0.411|
|[[:human genes:w:wdr87|WDR87]]|0.411|
|[[:human genes:a:akirin2|AKIRIN2]]|0.411|
|[[:human genes:t:tyms|TYMS]]|0.41|
|[[:human genes:t:timeless|TIMELESS]]|0.41|
|[[:human genes:p:pigs|PIGS]]|0.409|
|[[:human genes:m:mfrp|MFRP]]|0.409|
|[[:human genes:s:sart1|SART1]]|0.408|
|[[:human genes:i:ints5|INTS5]]|0.408|
|[[:human genes:r:rfpl3|RFPL3]]|0.407|
|[[:human genes:p:polr1a|POLR1A]]|0.407|
|[[:human genes:k:kif3c|KIF3C]]|0.406|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.406|
|[[:human genes:c:ccna2|CCNA2]]|0.406|
|[[:human genes:c:cln6|CLN6]]|0.404|
|[[:human genes:s:sprr2b|SPRR2B]]|0.402|
|[[:human genes:t:tspy8|TSPY8]]|0.402|
|[[:human genes:f:fbl|FBL]]|0.402|
|[[:human genes:m:map7d1|MAP7D1]]|0.402|
|[[:human genes:d:disp2|DISP2]]|0.401|
|[[:human genes:t:trappc11|TRAPPC11]]|0.401|
|[[:human genes:e:eif3a|EIF3A]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2001
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TP53TG3C Expression in NALM6 Cells: -6.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>