TPI1 [The Human Chemical-Genetic Interaction Map Project]

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======= TPI1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TPI1
  * **<color #00a2e8>Official Name</color>**: triosephosphate isomerase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7167|7167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60174|P60174]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TPI1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TPI1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/190450|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|methylglyoxal biosynthetic process|
|methylglyoxal synthase activity|
|triose-phosphate isomerase activity|
|glyceraldehyde-3-phosphate biosynthetic process|
|methylglyoxal metabolic process|
|glycerol catabolic process|
|glyceraldehyde-3-phosphate metabolic process|
|alditol catabolic process|
|aldehyde biosynthetic process|
|glycerol metabolic process|
|alditol metabolic process|
|polyol catabolic process|
|canonical glycolysis|
|glucose catabolic process to pyruvate|
|NADH regeneration|
|glycolytic process through fructose-6-phosphate|
|ketone biosynthetic process|
|glycolytic process through glucose-6-phosphate|
|glucose catabolic process|
|NADH metabolic process|
|cellular carbohydrate catabolic process|
|glycolytic process|
|ATP generation from ADP|
|gluconeogenesis|
|NAD metabolic process|
|hexose biosynthetic process|
|ADP metabolic process|
|hexose catabolic process|
|monosaccharide biosynthetic process|
|cellular aldehyde metabolic process|
|alcohol catabolic process|
|nucleoside diphosphate phosphorylation|
|purine nucleoside diphosphate metabolic process|
|monosaccharide catabolic process|
|nucleotide phosphorylation|
|purine ribonucleoside diphosphate metabolic process|
|ribonucleoside diphosphate metabolic process|
|pyruvate metabolic process|
|cellular ketone metabolic process|
|organic hydroxy compound catabolic process|
|nucleoside diphosphate metabolic process|
|polyol metabolic process|
|glucose metabolic process|
|carbohydrate catabolic process|
|carbohydrate biosynthetic process|
|hexose metabolic process|
|cellular carbohydrate metabolic process|
|monosaccharide metabolic process|
|ATP metabolic process|
|ubiquitin protein ligase binding|
|purine ribonucleotide metabolic process|
|alcohol metabolic process|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|ribose phosphate metabolic process|
|purine-containing compound metabolic process|
|generation of precursor metabolites and energy|
|small molecule catabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|organic hydroxy compound metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|small molecule biosynthetic process|
|carbohydrate derivative biosynthetic process|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|phosphorylation|
|extracellular space|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-2.25|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.01|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-1.96|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.87|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.81|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-1.8|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-1.78|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.77|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.77|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.76|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.7|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.74|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.77|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|1.81|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.01|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|2.18|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.6|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.544|
|[[:human genes:e:eno1|ENO1]]|0.533|
|[[:human genes:p:pgk1|PGK1]]|0.53|
|[[:human genes:t:tkt|TKT]]|0.523|
|[[:human genes:r:rpe|RPE]]|0.502|
|[[:human genes:s:srp14|SRP14]]|0.5|
|[[:human genes:p:pkm|PKM]]|0.478|
|[[:human genes:g:gemin8|GEMIN8]]|0.475|
|[[:human genes:t:tamm41|TAMM41]]|0.468|
|[[:human genes:c:crls1|CRLS1]]|0.458|
|[[:human genes:g:gemin6|GEMIN6]]|0.454|
|[[:human genes:n:n6amt1|N6AMT1]]|0.451|
|[[:human genes:u:uap1|UAP1]]|0.451|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.449|
|[[:human genes:z:znhit1|ZNHIT1]]|0.441|
|[[:human genes:r:rabggtb|RABGGTB]]|0.441|
|[[:human genes:r:romo1|ROMO1]]|0.421|
|[[:human genes:n:nsmce1|NSMCE1]]|0.42|
|[[:human genes:p:pmm2|PMM2]]|0.418|
|[[:human genes:s:srprb|SRPRB]]|0.412|
|[[:human genes:k:kdm8|KDM8]]|0.411|
|[[:human genes:p:ppcs|PPCS]]|0.411|
|[[:human genes:a:atxn10|ATXN10]]|0.41|
|[[:human genes:t:triap1|TRIAP1]]|0.406|
|[[:human genes:a:alg13|ALG13]]|0.402|
|[[:human genes:t:thg1l|THG1L]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 288/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|8/28|
|blood|12/28|
|bone|7/26|
|breast|10/33|
|central nervous system|21/56|
|cervix|1/4|
|colorectal|8/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|5/16|
|kidney|9/21|
|liver|3/20|
|lung|26/75|
|lymphocyte|9/16|
|ovary|9/26|
|pancreas|15/24|
|peripheral nervous system|9/16|
|plasma cell|4/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|15/22|
|urinary tract|14/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 344
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TPI1 Expression in NALM6 Cells: 8.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>