TRAF2 [The Human Chemical-Genetic Interaction Map Project]

This page is read only. You can view the source, but not change it. Ask your administrator if you think this is wrong.
======= TRAF2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAF2
  * **<color #00a2e8>Official Name</color>**: TNF receptor associated factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7186|7186]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12933|Q12933]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAF2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAF2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601895|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE. {ECO:0000269|PubMed:10346818, ECO:0000269|PubMed:11784851, ECO:0000269|PubMed:11907583, ECO:0000269|PubMed:12917689, ECO:0000269|PubMed:15121867, ECO:0000269|PubMed:15383523, ECO:0000269|PubMed:18981220, ECO:0000269|PubMed:19150425, ECO:0000269|PubMed:19506082, ECO:0000269|PubMed:19810754, ECO:0000269|PubMed:19918265, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:20047764, ECO:0000269|PubMed:20064526, ECO:0000269|PubMed:20385093, ECO:0000269|PubMed:20577214, ECO:0000269|PubMed:23453969}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-TRAF|
|MATH|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CD40 receptor binding|
|TRAF2-GSTP1 complex|
|sphingolipid binding|
|IRE1-TRAF2-ASK1 complex|
|positive regulation of I-kappaB phosphorylation|
|regulation of I-kappaB phosphorylation|
|death-inducing signaling complex assembly|
|negative regulation of glial cell apoptotic process|
|positive regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of glial cell apoptotic process|
|positive regulation of protein homodimerization activity|
|thioesterase binding|
|CD40 receptor complex|
|cellular response to nitric oxide|
|mitogen-activated protein kinase kinase kinase binding|
|activation of NF-kappaB-inducing kinase activity|
|cellular response to reactive nitrogen species|
|regulation of immunoglobulin secretion|
|positive regulation of T cell cytokine production|
|response to nitric oxide|
|regulation of protein homodimerization activity|
|programmed necrotic cell death|
|vesicle membrane|
|positive regulation of interleukin-2 production|
|necrotic cell death|
|tumor necrosis factor receptor binding|
|regulation of T cell cytokine production|
|protein homotrimerization|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|protein K63-linked ubiquitination|
|positive regulation of T cell mediated immunity|
|positive regulation of extrinsic apoptotic signaling pathway|
|positive regulation of cytokine-mediated signaling pathway|
|response to bronchodilator|
|cytoplasmic side of plasma membrane|
|protein trimerization|
|regulation of interleukin-2 production|
|positive regulation of cytokine production involved in immune response|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|positive regulation of response to cytokine stimulus|
|regulation of tumor necrosis factor-mediated signaling pathway|
|regulation of immunoglobulin production|
|protein autoubiquitination|
|I-kappaB kinase/NF-kappaB signaling|
|regulation of T cell mediated immunity|
|positive regulation of JUN kinase activity|
|positive regulation of NIK/NF-kappaB signaling|
|NIK/NF-kappaB signaling|
|regulation of cytokine production involved in immune response|
|protein phosphatase binding|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of JUN kinase activity|
|positive regulation of protein binding|
|extrinsic apoptotic signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of adaptive immune response|
|ubiquitin ligase complex|
|positive regulation of lymphocyte mediated immunity|
|protein heterooligomerization|
|regulation of NIK/NF-kappaB signaling|
|tumor necrosis factor-mediated signaling pathway|
|cellular response to reactive oxygen species|
|positive regulation of leukocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|cell cortex|
|positive regulation of JNK cascade|
|regulation of production of molecular mediator of immune response|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|intrinsic apoptotic signaling pathway|
|regulation of lymphocyte mediated immunity|
|positive regulation of cysteine-type endopeptidase activity|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of extrinsic apoptotic signaling pathway|
|regulation of adaptive immune response|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|positive regulation of endopeptidase activity|
|positive regulation of apoptotic signaling pathway|
|regulation of response to cytokine stimulus|
|positive regulation of binding|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of JNK cascade|
|positive regulation of peptidase activity|
|response to reactive oxygen species|
|regulation of leukocyte mediated immunity|
|negative regulation of neuron death|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|positive regulation of immune effector process|
|regulation of protein binding|
|cellular response to inorganic substance|
|negative regulation of apoptotic signaling pathway|
|membrane raft|
|regulation of stress-activated MAPK cascade|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of stress-activated protein kinase signaling cascade|
|cellular response to oxidative stress|
|cellular response to tumor necrosis factor|
|regulation of cysteine-type endopeptidase activity|
|ubiquitin-protein transferase activity|
|response to endoplasmic reticulum stress|
|positive regulation of MAP kinase activity|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|protein-containing complex binding|
|protein deubiquitination|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|protein polyubiquitination|
|regulation of neuron death|
|activation of protein kinase activity|
|positive regulation of protein serine/threonine kinase activity|
|protein homooligomerization|
|regulation of MAP kinase activity|
|enzyme binding|
|positive regulation of proteolysis|
|regulation of binding|
|response to oxidative stress|
|regulation of apoptotic signaling pathway|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of DNA-binding transcription factor activity|
|regulation of peptidase activity|
|positive regulation of cytokine production|
|protein kinase binding|
|regulation of protein secretion|
|regulation of immune effector process|
|regulation of peptide secretion|
|regulation of protein serine/threonine kinase activity|
|protein complex oligomerization|
|positive regulation of protein kinase activity|
|response to inorganic substance|
|positive regulation of MAPK cascade|
|positive regulation of kinase activity|
|protein-containing complex|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|positive regulation of hydrolase activity|
|protein modification by small protein conjugation|
|regulation of protein kinase activity|
|regulation of secretion|
|zinc ion binding|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|response to drug|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|response to cytokine|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|-4.62|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-3.11|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.98|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.78|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-2.76|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-2.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.68|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.65|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.47|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.41|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.27|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.24|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-2.16|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.11|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.09|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.08|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.08|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-2.04|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-2.02|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.99|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.93|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.91|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-1.85|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.84|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.81|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.81|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.8|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.79|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.79|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.77|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|-1.73|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:b:birc2|BIRC2]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 38/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|1/28|
|bone|0/26|
|breast|6/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2601
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAF2 Expression in NALM6 Cells: 4.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>