TRAPPC12 [The Human Chemical-Genetic Interaction Map Project]

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======= TRAPPC12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRAPPC12
  * **<color #00a2e8>Official Name</color>**: trafficking protein particle complex 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51112|51112]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WVT3|Q8WVT3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRAPPC12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRAPPC12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614139|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224). May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244). {ECO:0000269|PubMed:21525244, ECO:0000269|PubMed:25918224}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of kinetochore assembly|
|regulation of protein localization to kinetochore|
|positive regulation of protein localization to kinetochore|
|regulation of centromere complex assembly|
|TRAPP complex|
|metaphase plate congression|
|establishment of chromosome localization|
|chromosome localization|
|endoplasmic reticulum-Golgi intermediate compartment|
|endopeptidase activity|
|kinetochore|
|Golgi organization|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|nuclear chromosome segregation|
|regulation of organelle assembly|
|chromosome segregation|
|positive regulation of cellular protein localization|
|regulation of chromosome organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|endomembrane system organization|
|regulation of protein complex assembly|
|protein complex oligomerization|
|regulation of cellular protein localization|
|organelle localization|
|perinuclear region of cytoplasm|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|cell cycle process|
|regulation of protein localization|
|proteolysis|
|regulation of organelle organization|
|cell cycle|
|intracellular transport|
|protein-containing complex assembly|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.91|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.78|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.72|
|[[:results:exp144|PFI-3 10μM R03 exp144]]|2.01|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRAPPC12 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>