TREM2 [The Human Chemical-Genetic Interaction Map Project]

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======= TREM2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TREM2
  * **<color #00a2e8>Official Name</color>**: triggering receptor expressed on myeloid cells 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54209|54209]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZC2|Q9NZC2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TREM2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TREM2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605086|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. {ECO:0000269|PubMed:10799849}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of lipoteichoic acid|
|negative regulation of autophagic cell death|
|regulation of C-C chemokine receptor CCR7 signaling pathway|
|positive regulation of CD40 signaling pathway|
|positive regulation of CAMKK-AMPK signaling cascade|
|positive regulation of C-C chemokine receptor CCR7 signaling pathway|
|detection of peptidoglycan|
|positive regulation of inward rectifier potassium channel activity|
|positive regulation of engulfment of apoptotic cell|
|positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of antigen processing and presentation of peptide antigen|
|positive regulation of antigen processing and presentation of peptide antigen via MHC class II|
|very-low-density lipoprotein particle binding|
|regulation of CAMKK-AMPK signaling cascade|
|positive regulation of chemokine-mediated signaling pathway|
|regulation of autophagic cell death|
|regulation of engulfment of apoptotic cell|
|microglial cell activation involved in immune response|
|regulation of antigen processing and presentation of peptide antigen via MHC class II|
|regulation of inward rectifier potassium channel activity|
|detection of lipopolysaccharide|
|lipoteichoic acid binding|
|complement-mediated synapse pruning|
|regulation of macrophage fusion|
|cellular response to peptidoglycan|
|regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|positive regulation of microglial cell migration|
|apolipoprotein A-I binding|
|positive regulation of macrophage fusion|
|regulation of CD40 signaling pathway|
|regulation of antigen processing and presentation of peptide antigen|
|regulation of macrophage inflammatory protein 1 alpha production|
|microglial cell proliferation|
|regulation of microglial cell migration|
|macrophage proliferation|
|positive regulation of amyloid-beta clearance|
|lipoprotein particle binding|
|positive regulation of microglial cell activation|
|positive regulation of apoptotic cell clearance|
|regulation of resting membrane potential|
|positive regulation of glial cell migration|
|positive regulation of antigen processing and presentation|
|high-density lipoprotein particle binding|
|regulation of apoptotic cell clearance|
|cellular response to lipoteichoic acid|
|response to lipoteichoic acid|
|regulation of chemokine-mediated signaling pathway|
|response to peptidoglycan|
|synapse pruning|
|detection of molecule of bacterial origin|
|positive regulation of ATP biosynthetic process|
|positive regulation of phagocytosis, engulfment|
|positive regulation of membrane invagination|
|macrophage activation involved in immune response|
|positive regulation of neuroinflammatory response|
|regulation of phagocytosis, engulfment|
|positive regulation of voltage-gated potassium channel activity|
|regulation of glial cell migration|
|regulation of amyloid-beta clearance|
|apolipoprotein binding|
|regulation of membrane invagination|
|glial cell proliferation|
|low-density lipoprotein particle binding|
|peptidoglycan binding|
|regulation of microglial cell activation|
|regulation of ATP biosynthetic process|
|astrocyte activation|
|detection of external biotic stimulus|
|regulation of antigen processing and presentation|
|positive regulation of macrophage migration|
|positive regulation of nucleotide biosynthetic process|
|amyloid-beta clearance|
|positive regulation of purine nucleotide biosynthetic process|
|detection of biotic stimulus|
|positive regulation of macrophage activation|
|positive regulation of potassium ion transmembrane transporter activity|
|positive regulation of osteoclast differentiation|
|protein tyrosine kinase binding|
|positive regulation of syncytium formation by plasma membrane fusion|
|negative regulation of interleukin-1 beta production|
|regulation of syncytium formation by plasma membrane fusion|
|leukocyte activation involved in inflammatory response|
|microglial cell activation|
|regulation of neuroinflammatory response|
|dendritic cell differentiation|
|negative regulation of interleukin-1 production|
|lipopolysaccharide binding|
|astrocyte development|
|positive regulation of interleukin-10 production|
|intrinsic component of plasma membrane|
|regulation of macrophage migration|
|positive regulation of potassium ion transmembrane transport|
|glial cell activation|
|cellular response to amyloid-beta|
|apoptotic cell clearance|
|positive regulation of TOR signaling|
|regulation of purine nucleotide biosynthetic process|
|regulation of nucleotide biosynthetic process|
|neuroinflammatory response|
|positive regulation of calcium-mediated signaling|
|osteoclast differentiation|
|positive regulation of nucleotide metabolic process|
|positive regulation of ATP metabolic process|
|positive regulation of potassium ion transport|
|positive regulation of purine nucleotide metabolic process|
|response to amyloid-beta|
|response to ischemia|
|macrophage activation|
|positive regulation of cytokine-mediated signaling pathway|
|regulation of macrophage activation|
|regulation of interleukin-10 production|
|astrocyte differentiation|
|positive regulation of myeloid leukocyte differentiation|
|positive regulation of protein localization to plasma membrane|
|regulation of potassium ion transmembrane transporter activity|
|positive regulation of response to cytokine stimulus|
|negative regulation of tumor necrosis factor production|
|scaffold protein binding|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|positive regulation of protein localization to cell periphery|
|regulation of osteoclast differentiation|
|positive regulation of phagocytosis|
|positive regulation of cation channel activity|
|positive regulation of gliogenesis|
|positive regulation of NIK/NF-kappaB signaling|
|regulation of chemokine production|
|regulation of potassium ion transmembrane transport|
|regulation of interleukin-1 beta production|
|amyloid-beta binding|
|negative regulation of autophagy|
|positive regulation of myeloid cell differentiation|
|regulation of protein localization to plasma membrane|
|regulation of interleukin-1 production|
|regulation of phagocytosis|
|regulation of potassium ion transport|
|regulation of calcium-mediated signaling|
|leukocyte proliferation|
|positive regulation of endocytosis|
|regulation of TOR signaling|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of ion transmembrane transporter activity|
|phospholipid binding|
|glial cell development|
|regulation of NIK/NF-kappaB signaling|
|myeloid leukocyte differentiation|
|positive regulation of transporter activity|
|regulation of protein localization to cell periphery|
|positive regulation of mitochondrion organization|
|regulation of gliogenesis|
|regulation of myeloid leukocyte differentiation|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|regulation of ATP metabolic process|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein localization to membrane|
|phagocytosis, engulfment|
|positive regulation of leukocyte migration|
|positive regulation of chemotaxis|
|positive regulation of small molecule metabolic process|
|plasma membrane invagination|
|positive regulation of inflammatory response|
|regulation of interleukin-6 production|
|positive regulation of cellular protein catabolic process|
|positive regulation of cation transmembrane transport|
|membrane invagination|
|positive regulation of leukocyte differentiation|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|lipid binding|
|positive regulation of ion transmembrane transport|
|regulation of cytokine-mediated signaling pathway|
|glial cell differentiation|
|regulation of cation channel activity|
|regulation of response to cytokine stimulus|
|regulation of mitochondrion organization|
|regulation of proteasomal protein catabolic process|
|positive regulation of hemopoiesis|
|regulation of protein localization to membrane|
|positive regulation of peptidyl-tyrosine phosphorylation|
|cellular response to molecule of bacterial origin|
|regulation of leukocyte migration|
|positive regulation of transmembrane transport|
|signaling receptor activity|
|regulation of endocytosis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|gliogenesis|
|cellular response to biotic stimulus|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|myeloid cell differentiation|
|regulation of myeloid cell differentiation|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|regulation of peptidyl-tyrosine phosphorylation|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|protein-containing complex binding|
|positive regulation of protein secretion|
|synapse organization|
|regulation of leukocyte differentiation|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|positive regulation of cellular protein localization|
|cellular response to peptide|
|response to molecule of bacterial origin|
|phagocytosis|
|defense response to bacterium|
|leukocyte differentiation|
|regulation of autophagy|
|regulation of cation transmembrane transport|
|regulation of inflammatory response|
|humoral immune response|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|cellular component disassembly|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|positive regulation of protein transport|
|regulation of small molecule metabolic process|
|regulation of membrane potential|
|positive regulation of catabolic process|
|positive regulation of secretion|
|positive regulation of cytokine production|
|regulation of hemopoiesis|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|positive regulation of neurogenesis|
|response to peptide|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|myeloid cell activation involved in immune response|
|detection of chemical stimulus|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cellular protein localization|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|cell population proliferation|
|endocytosis|
|hemopoiesis|
|regulation of transmembrane transport|
|myeloid leukocyte activation|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|import into cell|
|detection of stimulus|
|response to bacterium|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of protein transport|
|regulation of cell projection organization|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|regulation of secretion|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|regulation of cell migration|
|response to lipid|
|membrane organization|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|regulation of catabolic process|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|cell development|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|extracellular region|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TREM2 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>