TREX1 [The Human Chemical-Genetic Interaction Map Project]

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======= TREX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TREX1
  * **<color #00a2e8>Official Name</color>**: three prime repair exonuclease 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11277|11277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NSU2|Q9NSU2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TREX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TREX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606609|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. {ECO:0000269|PubMed:10391904, ECO:0000269|PubMed:10393201, ECO:0000269|PubMed:16818237, ECO:0000269|PubMed:17293595, ECO:0000269|PubMed:18045533, ECO:0000269|PubMed:23993650}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|immune complex formation|
|immune response in brain or nervous system|
|detection of endogenous biotic stimulus|
|detection of DNA damage stimulus involved in DNA damage checkpoint|
|immunoglobulin biosynthetic process involved in immune response|
|detection of stimulus involved in cell cycle checkpoint|
|adenyl deoxyribonucleotide binding|
|CD86 biosynthetic process|
|immunoglobulin biosynthetic process|
|DNA synthesis involved in UV-damage excision repair|
|interferon-alpha production|
|T cell antigen processing and presentation|
|transposition, RNA-mediated|
|detection of endogenous stimulus|
|exodeoxyribonuclease III activity|
|regulation of lysosome organization|
|3-5-exodeoxyribonuclease activity|
|transposition|
|atrial cardiac muscle tissue development|
|MutSalpha complex binding|
|MutLalpha complex binding|
|type I interferon production|
|regulation of protein complex stability|
|cellular response to hydroxyurea|
|response to hydroxyurea|
|nuclear replication fork|
|oligosaccharyltransferase complex|
|lymphoid progenitor cell differentiation|
|macrophage activation involved in immune response|
|negative regulation of type I interferon-mediated signaling pathway|
|UV-damage excision repair|
|response to antimetabolite|
|determination of adult lifespan|
|3-5 exonuclease activity|
|DNA binding, bending|
|cellular response to interferon-beta|
|detection of biotic stimulus|
|inflammatory response to antigenic stimulus|
|immunoglobulin production involved in immunoglobulin mediated immune response|
|response to interferon-beta|
|DNA catabolic process|
|cellular response to gamma radiation|
|regulation of cellular respiration|
|WW domain binding|
|organ or tissue specific immune response|
|mismatch repair|
|regulation of type I interferon-mediated signaling pathway|
|multicellular organism aging|
|apoptotic cell clearance|
|DNA damage response, detection of DNA damage|
|regulation of vacuole organization|
|T cell mediated immunity|
|protein-DNA complex|
|macrophage activation|
|DNA synthesis involved in DNA repair|
|negative regulation of innate immune response|
|response to gamma radiation|
|negative regulation of cytokine-mediated signaling pathway|
|regulation of immunoglobulin production|
|negative regulation of response to cytokine stimulus|
|type I interferon signaling pathway|
|cellular response to type I interferon|
|cellular response to ionizing radiation|
|response to type I interferon|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|regulation of glycolytic process|
|cellular response to UV|
|hematopoietic progenitor cell differentiation|
|regulation of fatty acid metabolic process|
|regulation of carbohydrate catabolic process|
|DNA modification|
|negative regulation of response to biotic stimulus|
|response to antineoplastic agent|
|heart process|
|double-stranded DNA binding|
|signal transduction in response to DNA damage|
|single-stranded DNA binding|
|DNA biosynthetic process|
|DNA duplex unwinding|
|cellular response to light stimulus|
|regulation of purine nucleotide metabolic process|
|regulation of nucleotide metabolic process|
|DNA geometric change|
|regulation of ATP metabolic process|
|regulation of type I interferon production|
|cellular response to reactive oxygen species|
|DNA damage checkpoint|
|regulation of production of molecular mediator of immune response|
|response to UV|
|DNA integrity checkpoint|
|regulation of tumor necrosis factor production|
|response to ionizing radiation|
|negative regulation of immune response|
|cytokine production|
|regulation of tumor necrosis factor superfamily cytokine production|
|immunoglobulin production|
|regulation of generation of precursor metabolites and energy|
|regulation of cytokine-mediated signaling pathway|
|regulation of cellular ketone metabolic process|
|cellular response to radiation|
|regulation of response to cytokine stimulus|
|protein stabilization|
|nuclear envelope|
|production of molecular mediator of immune response|
|regulation of lipid biosynthetic process|
|defense response to virus|
|cell cycle checkpoint|
|response to reactive oxygen species|
|regulation of carbohydrate metabolic process|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|B cell mediated immunity|
|DNA replication|
|negative regulation of multi-organism process|
|magnesium ion binding|
|antigen processing and presentation|
|cellular response to inorganic substance|
|DNA recombination|
|cellular response to oxidative stress|
|heart morphogenesis|
|lymphocyte mediated immunity|
|kidney development|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|aging|
|response to virus|
|renal system development|
|regulation of protein stability|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|regulation of T cell activation|
|urogenital system development|
|glycoprotein biosynthetic process|
|phagocytosis|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|nucleobase-containing compound catabolic process|
|response to oxidative stress|
|glycoprotein metabolic process|
|regulation of lipid metabolic process|
|circulatory system process|
|cellular response to drug|
|generation of precursor metabolites and energy|
|regulation of small molecule metabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|response to radiation|
|negative regulation of immune system process|
|aromatic compound catabolic process|
|regulation of innate immune response|
|regulation of immune effector process|
|organic cyclic compound catabolic process|
|blood vessel development|
|inflammatory response|
|DNA repair|
|vasculature development|
|regulation of lymphocyte activation|
|cardiovascular system development|
|myeloid cell activation involved in immune response|
|regulation of response to biotic stimulus|
|heart development|
|response to inorganic substance|
|hemopoiesis|
|negative regulation of cell cycle|
|myeloid leukocyte activation|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|carbohydrate derivative biosynthetic process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|regulation of cell activation|
|immune system development|
|cellular response to nitrogen compound|
|cytokine-mediated signaling pathway|
|detection of stimulus|
|regulation of cytokine production|
|DNA metabolic process|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|positive regulation of immune response|
|circulatory system development|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|defense response to other organism|
|animal organ morphogenesis|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|response to drug|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|chromosome organization|
|cell activation|
|response to nitrogen compound|
|immune effector process|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|immune response|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6828
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TREX1 Expression in NALM6 Cells: 4.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>