TRIB3 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIB3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIB3
  * **<color #00a2e8>Official Name</color>**: tribbles pseudokinase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57761|57761]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96RU7|Q96RU7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIB3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIB3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-protein transferase regulator activity|
|mitogen-activated protein kinase kinase binding|
|negative regulation of fatty acid biosynthetic process|
|negative regulation of fatty acid metabolic process|
|protein kinase inhibitor activity|
|positive regulation of ubiquitin-protein transferase activity|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|regulation of fatty acid biosynthetic process|
|negative regulation of fat cell differentiation|
|negative regulation of protein kinase B signaling|
|negative regulation of lipid biosynthetic process|
|regulation of ubiquitin-protein transferase activity|
|regulation of glucose transmembrane transport|
|kinase activity|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of lipid metabolic process|
|regulation of fatty acid metabolic process|
|negative regulation of small molecule metabolic process|
|positive regulation of protein binding|
|positive regulation of ubiquitin-dependent protein catabolic process|
|positive regulation of proteasomal protein catabolic process|
|positive regulation of protein ubiquitination|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of fat cell differentiation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|positive regulation of protein modification by small protein conjugation or removal|
|positive regulation of cellular protein catabolic process|
|intrinsic apoptotic signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|cellular response to insulin stimulus|
|regulation of cellular ketone metabolic process|
|positive regulation of binding|
|regulation of proteasomal protein catabolic process|
|regulation of lipid biosynthetic process|
|regulation of protein ubiquitination|
|positive regulation of protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein binding|
|regulation of protein kinase B signaling|
|negative regulation of protein kinase activity|
|response to insulin|
|regulation of protein modification by small protein conjugation or removal|
|transcription corepressor activity|
|negative regulation of kinase activity|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|cellular response to peptide hormone stimulus|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|cellular response to peptide|
|regulation of autophagy|
|regulation of MAP kinase activity|
|positive regulation of proteolysis|
|positive regulation of cellular catabolic process|
|regulation of binding|
|regulation of protein catabolic process|
|response to peptide hormone|
|regulation of lipid metabolic process|
|negative regulation of protein phosphorylation|
|regulation of small molecule metabolic process|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|protein kinase binding|
|response to peptide|
|negative regulation of intracellular signal transduction|
|regulation of protein serine/threonine kinase activity|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|positive regulation of transferase activity|
|cellular response to nitrogen compound|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of MAPK cascade|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|regulation of kinase activity|
|response to hormone|
|apoptotic process|
|negative regulation of developmental process|
|protein phosphorylation|
|regulation of transferase activity|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|cell death|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|phosphorylation|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-2.64|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13631
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIB3 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>