TRIM23 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM23
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 23
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=373|373]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36406|P36406]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601747|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as an E3 ubiquitin-protein ligase. Plays an essential role in autophagy activation during viral infection. Mechanistically, activates TANK-binding kinase 1/TBK1 by facilitating its dimerization and ability to phosphorylate the selective autophagy receptor SQSTM1. In order to achieve this function, TRIM23 mediates 'Lys-27'-linked auto-ubiquitination of its ADP-ribosylation factor (ARF) domain to induce its GTPase activity and its recruitment to autophagosomes (PubMed:28871090). {ECO:0000269|PubMed:15684077, ECO:0000269|PubMed:28871090}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Miro|
|Arf|
|SRPRB|
|Ras|
|G-alpha|
|zf-B box|
|Gtr1 RagA|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|enzyme activator activity|
|Golgi to plasma membrane transport|
|GDP binding|
|vesicle-mediated transport to the plasma membrane|
|post-Golgi vesicle-mediated transport|
|nucleic acid binding|
|ubiquitin-protein transferase activity|
|lysosomal membrane|
|GTPase activity|
|Golgi vesicle transport|
|GTP binding|
|Golgi membrane|
|protein ubiquitination|
|viral process|
|innate immune response|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|zinc ion binding|
|defense response to other organism|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|identical protein binding|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of catalytic activity|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|positive regulation of molecular function|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.3|
|[[:results:exp115|A-366 10μM R03 exp115]]|-1.85|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.84|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.75|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.76|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.89|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.92|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.97|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.97|
|[[:results:exp358|FK-506 5μM R07 exp358]]|2.04|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|2.09|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.22|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM23 Expression in NALM6 Cells: 3.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>