TRIM9 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM9
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=114088|114088]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9C026|Q9C026]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606555|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000269|PubMed:20085810}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-B box|
|zf-C3HC4|
|fn3|
|SPRY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of SNARE complex assembly|
|negative regulation of vesicle fusion|
|negative regulation of calcium ion-dependent exocytosis|
|regulation of SNARE complex assembly|
|presynaptic cytosol|
|negative regulation of regulated secretory pathway|
|regulation of vesicle fusion|
|negative regulation of exocytosis|
|regulation of calcium ion-dependent exocytosis|
|synaptic vesicle exocytosis|
|SNARE binding|
|neurotransmitter secretion|
|signal release from synapse|
|synaptic vesicle cycle|
|synaptic vesicle|
|vesicle-mediated transport in synapse|
|negative regulation of protein complex assembly|
|regulation of regulated secretory pathway|
|signal release|
|neurotransmitter transport|
|negative regulation of secretion by cell|
|regulation of exocytosis|
|negative regulation of secretion|
|protein domain specific binding|
|ubiquitin-protein transferase activity|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of neurotransmitter levels|
|cytoskeleton|
|negative regulation of organelle organization|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|regulation of protein complex assembly|
|synaptic signaling|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell junction|
|regulation of vesicle-mediated transport|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulated exocytosis|
|negative regulation of cellular component organization|
|regulation of secretion by cell|
|protein modification by small protein conjugation|
|exocytosis|
|regulation of secretion|
|zinc ion binding|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|secretion by cell|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell-cell signaling|
|secretion|
|proteolysis|
|regulation of organelle organization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.71|
|[[:results:exp516|Pyrazinamide 100μM R08 exp516]]|1.77|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10974
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.36 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM9 Expression in NALM6 Cells: 2.36'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>