TRMT10C [The Human Chemical-Genetic Interaction Map Project]

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======= TRMT10C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT10C
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 10C, mitochondrial RNase P subunit
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54931|54931]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L0Y3|Q7L0Y3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT10C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT10C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation (PubMed:18984158, PubMed:21593607, PubMed:23042678, PubMed:27132592). Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158). Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)- methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit (PubMed:23042678). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'- end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA (PubMed:29072297). {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:21593607, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:27132592, ECO:0000269|PubMed:29040705, ECO:0000269|PubMed:29072297}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA m1G MT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA (adenine-N1-)-methyltransferase activity|
|tRNA (guanine(9)-N(1))-methyltransferase activity|
|mitochondrial tRNA 5-end processing|
|mitochondrial ribonuclease P complex|
|mitochondrial tRNA 3-end processing|
|tRNA (guanine-N1-)-methyltransferase activity|
|mitochondrial RNA 5-end processing|
|tRNA (adenine-N1-)-methyltransferase activity|
|mitochondrial RNA 3-end processing|
|mitochondrial tRNA methylation|
|mitochondrial RNA modification|
|mitochondrial tRNA modification|
|tRNA 3-end processing|
|mitochondrial tRNA processing|
|mRNA methylation|
|tRNA 5-end processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|positive regulation of mitochondrial translation|
|mitochondrial RNA processing|
|ncRNA 5-end processing|
|RNA 5-end processing|
|mRNA modification|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|tRNA methylation|
|mitochondrial RNA metabolic process|
|mitochondrial nucleoid|
|ncRNA 3-end processing|
|tRNA binding|
|RNA methylation|
|tRNA modification|
|positive regulation of translation|
|tRNA processing|
|RNA 3-end processing|
|mitochondrial gene expression|
|positive regulation of cellular amide metabolic process|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|regulation of translation|
|mitochondrial matrix|
|ncRNA processing|
|regulation of cellular amide metabolic process|
|ncRNA metabolic process|
|posttranscriptional regulation of gene expression|
|mRNA metabolic process|
|RNA processing|
|mitochondrion|
|RNA binding|
|positive regulation of cellular protein metabolic process|
|RNA metabolic process|
|positive regulation of protein metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.7|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps21|MRPS21]]|0.525|
|[[:human genes:t:tufm|TUFM]]|0.484|
|[[:human genes:d:dap3|DAP3]]|0.483|
|[[:human genes:g:gfm1|GFM1]]|0.475|
|[[:human genes:c:cox16|COX16]]|0.473|
|[[:human genes:n:nars2|NARS2]]|0.472|
|[[:human genes:m:mrp63|MRP63]]|0.466|
|[[:human genes:m:mrpl53|MRPL53]]|0.464|
|[[:human genes:p:pnpt1|PNPT1]]|0.463|
|[[:human genes:t:tefm|TEFM]]|0.459|
|[[:human genes:n:ndufa1|NDUFA1]]|0.458|
|[[:human genes:m:mrpl23|MRPL23]]|0.457|
|[[:human genes:y:yars2|YARS2]]|0.457|
|[[:human genes:d:dars2|DARS2]]|0.456|
|[[:human genes:m:mrpl21|MRPL21]]|0.454|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.454|
|[[:human genes:n:ndufb11|NDUFB11]]|0.449|
|[[:human genes:t:trub2|TRUB2]]|0.446|
|[[:human genes:v:vars2|VARS2]]|0.445|
|[[:human genes:m:mrpl45|MRPL45]]|0.442|
|[[:human genes:m:mrps5|MRPS5]]|0.438|
|[[:human genes:m:mars2|MARS2]]|0.436|
|[[:human genes:m:mrps14|MRPS14]]|0.429|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.427|
|[[:human genes:r:rars2|RARS2]]|0.425|
|[[:human genes:m:mrpl15|MRPL15]]|0.424|
|[[:human genes:q:qrsl1|QRSL1]]|0.422|
|[[:human genes:m:mrps16|MRPS16]]|0.418|
|[[:human genes:m:mrpl18|MRPL18]]|0.417|
|[[:human genes:a:atp5sl|ATP5SL]]|0.409|
|[[:human genes:n:nfu1|NFU1]]|0.408|
|[[:human genes:r:rbfa|RBFA]]|0.408|
|[[:human genes:t:tomm20|TOMM20]]|0.408|
|[[:human genes:c:cox17|COX17]]|0.408|
|[[:human genes:n:ndufa11|NDUFA11]]|0.407|
|[[:human genes:w:wbscr16|WBSCR16]]|0.407|
|[[:human genes:m:mrps18a|MRPS18A]]|0.406|
|[[:human genes:m:mrpl3|MRPL3]]|0.405|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.404|
|[[:human genes:g:grsf1|GRSF1]]|0.402|
|[[:human genes:m:mrps26|MRPS26]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 736
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT10C Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>