TRMT5 [The Human Chemical-Genetic Interaction Map Project]

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======= TRMT5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRMT5
  * **<color #00a2e8>Official Name</color>**: tRNA methyltransferase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57570|57570]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q32P41|Q32P41]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRMT5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRMT5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611023|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  tRNAs contain as many as 13 or 14 nucleotides that are modified posttranscriptionally by enzymes that are highly specific for particular nucleotides in the tRNA structure. TRMT5 methylates the N1 position of guanosine-37 (G37) in selected tRNAs using S-adenosyl methionine (Brule et al., 2004 [PubMed 15248782]).[supplied by OMIM, Mar 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. {ECO:0000269|PubMed:26189817}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Met 10|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA N1-guanine methylation|
|tRNA (guanine(37)-N(1))-methyltransferase activity|
|tRNA (guanine-N1-)-methyltransferase activity|
|mitochondrial tRNA methylation|
|tRNA methyltransferase activity|
|mitochondrial tRNA modification|
|mitochondrial RNA modification|
|mitochondrial tRNA processing|
|tRNA threonylcarbamoyladenosine metabolic process|
|mitochondrial RNA processing|
|mitochondrial RNA metabolic process|
|tRNA methylation|
|RNA methylation|
|tRNA modification|
|tRNA processing|
|mitochondrial gene expression|
|RNA modification|
|tRNA metabolic process|
|macromolecule methylation|
|methylation|
|mitochondrial matrix|
|ncRNA processing|
|ncRNA metabolic process|
|RNA processing|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.11|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-2.07|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.96|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.89|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.82|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.82|
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.73|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|1.7|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.77|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pmm2|PMM2]]|0.64|
|[[:human genes:r:rtcb|RTCB]]|0.615|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.61|
|[[:human genes:a:alg1|ALG1]]|0.599|
|[[:human genes:t:thg1l|THG1L]]|0.589|
|[[:human genes:t:tti1|TTI1]]|0.587|
|[[:human genes:d:dpagt1|DPAGT1]]|0.577|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.554|
|[[:human genes:r:rptor|RPTOR]]|0.544|
|[[:human genes:a:atxn10|ATXN10]]|0.543|
|[[:human genes:p:polr3b|POLR3B]]|0.539|
|[[:human genes:t:triap1|TRIAP1]]|0.534|
|[[:human genes:t:tti2|TTI2]]|0.529|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.528|
|[[:human genes:r:rad1|RAD1]]|0.527|
|[[:human genes:h:hars|HARS]]|0.527|
|[[:human genes:n:nae1|NAE1]]|0.526|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.522|
|[[:human genes:g:gmppb|GMPPB]]|0.521|
|[[:human genes:u:uap1|UAP1]]|0.521|
|[[:human genes:g:gnb1l|GNB1L]]|0.52|
|[[:human genes:p:polr3h|POLR3H]]|0.519|
|[[:human genes:r:rpp21|RPP21]]|0.517|
|[[:human genes:u:uhrf1|UHRF1]]|0.515|
|[[:human genes:r:rnmt|RNMT]]|0.513|
|[[:human genes:o:otud5|OTUD5]]|0.51|
|[[:human genes:n:nsmce1|NSMCE1]]|0.508|
|[[:human genes:u:uba3|UBA3]]|0.506|
|[[:human genes:a:alg5|ALG5]]|0.505|
|[[:human genes:p:ppp4c|PPP4C]]|0.505|
|[[:human genes:c:cbx3|CBX3]]|0.502|
|[[:human genes:p:pelo|PELO]]|0.5|
|[[:human genes:a:alg2|ALG2]]|0.499|
|[[:human genes:s:slc25a19|SLC25A19]]|0.497|
|[[:human genes:a:adsl|ADSL]]|0.496|
|[[:human genes:a:aars|AARS]]|0.492|
|[[:human genes:g:gtf3c5|GTF3C5]]|0.491|
|[[:human genes:s:srp14|SRP14]]|0.49|
|[[:human genes:s:slc25a26|SLC25A26]]|0.488|
|[[:human genes:g:gfpt1|GFPT1]]|0.488|
|[[:human genes:r:rpe|RPE]]|0.483|
|[[:human genes:r:rfk|RFK]]|0.483|
|[[:human genes:e:eny2|ENY2]]|0.48|
|[[:human genes:t:ttc4|TTC4]]|0.479|
|[[:human genes:c:cep57|CEP57]]|0.479|
|[[:human genes:n:nars|NARS]]|0.478|
|[[:human genes:f:fh|FH]]|0.478|
|[[:human genes:v:vezt|VEZT]]|0.477|
|[[:human genes:t:trnt1|TRNT1]]|0.473|
|[[:human genes:y:yars|YARS]]|0.472|
|[[:human genes:c:cct7|CCT7]]|0.47|
|[[:human genes:t:tsen54|TSEN54]]|0.468|
|[[:human genes:z:zrsr2|ZRSR2]]|0.466|
|[[:human genes:e:eef1e1|EEF1E1]]|0.466|
|[[:human genes:t:telo2|TELO2]]|0.463|
|[[:human genes:r:rbm14|RBM14]]|0.463|
|[[:human genes:d:dohh|DOHH]]|0.461|
|[[:human genes:m:med16|MED16]]|0.458|
|[[:human genes:w:wdr24|WDR24]]|0.457|
|[[:human genes:l:lsm10|LSM10]]|0.457|
|[[:human genes:r:rabggtb|RABGGTB]]|0.457|
|[[:human genes:c:ccdc101|CCDC101]]|0.456|
|[[:human genes:e:eif4e|EIF4E]]|0.455|
|[[:human genes:t:tmem41b|TMEM41B]]|0.455|
|[[:human genes:t:tle4|TLE4]]|0.455|
|[[:human genes:m:mllt1|MLLT1]]|0.454|
|[[:human genes:g:gemin5|GEMIN5]]|0.453|
|[[:human genes:c:csnk2b|CSNK2B]]|0.452|
|[[:human genes:v:vmp1|VMP1]]|0.451|
|[[:human genes:p:ppp6c|PPP6C]]|0.451|
|[[:human genes:m:med4|MED4]]|0.45|
|[[:human genes:m:mapk14|MAPK14]]|0.449|
|[[:human genes:e:elp3|ELP3]]|0.449|
|[[:human genes:a:alg14|ALG14]]|0.447|
|[[:human genes:d:dad1|DAD1]]|0.447|
|[[:human genes:e:exoc4|EXOC4]]|0.445|
|[[:human genes:t:txnl4b|TXNL4B]]|0.445|
|[[:human genes:a:atp5b|ATP5B]]|0.443|
|[[:human genes:a:alg6|ALG6]]|0.443|
|[[:human genes:a:atp5j|ATP5J]]|0.443|
|[[:human genes:d:ddx1|DDX1]]|0.442|
|[[:human genes:o:osgep|OSGEP]]|0.441|
|[[:human genes:g:gemin8|GEMIN8]]|0.439|
|[[:human genes:n:nbn|NBN]]|0.439|
|[[:human genes:p:ppcs|PPCS]]|0.439|
|[[:human genes:v:vrk1|VRK1]]|0.438|
|[[:human genes:u:ubr5|UBR5]]|0.438|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.438|
|[[:human genes:m:meaf6|MEAF6]]|0.438|
|[[:human genes:s:ssb|SSB]]|0.433|
|[[:human genes:u:ube2j1|UBE2J1]]|0.433|
|[[:human genes:h:hspd1|HSPD1]]|0.432|
|[[:human genes:p:ptchd3|PTCHD3]]|0.431|
|[[:human genes:f:fnta|FNTA]]|0.429|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.429|
|[[:human genes:z:znf608|ZNF608]]|0.428|
|[[:human genes:t:thoc6|THOC6]]|0.427|
|[[:human genes:u:ube2l3|UBE2L3]]|0.427|
|[[:human genes:d:dhps|DHPS]]|0.427|
|[[:human genes:t:txnrd1|TXNRD1]]|0.426|
|[[:human genes:x:xpot|XPOT]]|0.426|
|[[:human genes:a:atrx|ATRX]]|0.425|
|[[:human genes:e:eprs|EPRS]]|0.424|
|[[:human genes:n:nup50|NUP50]]|0.423|
|[[:human genes:s:stt3a|STT3A]]|0.421|
|[[:human genes:e:elac2|ELAC2]]|0.42|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.419|
|[[:human genes:u:ube2m|UBE2M]]|0.419|
|[[:human genes:u:ube2k|UBE2K]]|0.419|
|[[:human genes:g:gemin6|GEMIN6]]|0.418|
|[[:human genes:a:atic|ATIC]]|0.418|
|[[:human genes:a:atp5o|ATP5O]]|0.415|
|[[:human genes:r:rft1|RFT1]]|0.415|
|[[:human genes:h:haus8|HAUS8]]|0.414|
|[[:human genes:c:cbfb|CBFB]]|0.413|
|[[:human genes:p:pam16|PAM16]]|0.413|
|[[:human genes:n:nsmce2|NSMCE2]]|0.412|
|[[:human genes:t:timm22|TIMM22]]|0.412|
|[[:human genes:e:elp2|ELP2]]|0.411|
|[[:human genes:t:tbca|TBCA]]|0.411|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.409|
|[[:human genes:m:med25|MED25]]|0.409|
|[[:human genes:t:tkt|TKT]]|0.409|
|[[:human genes:c:ciao1|CIAO1]]|0.408|
|[[:human genes:u:urm1|URM1]]|0.408|
|[[:human genes:d:dhx29|DHX29]]|0.408|
|[[:human genes:r:romo1|ROMO1]]|0.407|
|[[:human genes:o:orc5|ORC5]]|0.407|
|[[:human genes:d:ddx20|DDX20]]|0.407|
|[[:human genes:p:pdap1|PDAP1]]|0.406|
|[[:human genes:s:sdha|SDHA]]|0.402|
|[[:human genes:w:wdr59|WDR59]]|0.402|
|[[:human genes:d:dolk|DOLK]]|0.401|
|[[:human genes:s:sec61g|SEC61G]]|0.4|
|[[:human genes:c:ctc1|CTC1]]|0.4|
|[[:human genes:b:bub3|BUB3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 39/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|1/26|
|breast|1/33|
|central nervous system|7/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|2/20|
|lung|3/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|2/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 304
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRMT5 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>