TRPC5 [The Human Chemical-Genetic Interaction Map Project]

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======= TRPC5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPC5
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily C member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7224|7224]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UL62|Q9UL62]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPC5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPC5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300334|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. {ECO:0000250, ECO:0000269|PubMed:16284075}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ion trans|
|TRP 2|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of membrane hyperpolarization|
|store-operated calcium channel activity|
|cation channel complex|
|actinin binding|
|manganese ion transport|
|inositol 1,4,5 trisphosphate binding|
|negative regulation of dendrite morphogenesis|
|calcium channel complex|
|positive regulation of peptidyl-threonine phosphorylation|
|negative regulation of dendrite development|
|clathrin binding|
|positive regulation of axon extension|
|regulation of peptidyl-threonine phosphorylation|
|calcium channel activity|
|ATPase binding|
|positive regulation of axonogenesis|
|regulation of dendrite morphogenesis|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|regulation of extent of cell growth|
|transition metal ion transport|
|growth cone|
|regulation of dendrite development|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|regulation of cell size|
|negative regulation of cell projection organization|
|regulation of axonogenesis|
|calcium ion transmembrane transport|
|membrane raft|
|negative regulation of neuron differentiation|
|calcium ion transport|
|positive regulation of growth|
|actin binding|
|positive regulation of neuron projection development|
|positive regulation of cytosolic calcium ion concentration|
|negative regulation of neurogenesis|
|divalent metal ion transport|
|divalent inorganic cation transport|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of nervous system development|
|regulation of cytosolic calcium ion concentration|
|regulation of developmental growth|
|negative regulation of cell development|
|positive regulation of neuron differentiation|
|neuronal cell body|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|regulation of cell growth|
|dendrite|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|positive regulation of neurogenesis|
|divalent inorganic cation homeostasis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|regulation of neurogenesis|
|cation transport|
|cellular homeostasis|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|ion transmembrane transport|
|positive regulation of cell differentiation|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|homeostatic process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10115
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.52 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPC5 Expression in NALM6 Cells: -1.52'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>