TRPM7 [The Human Chemical-Genetic Interaction Map Project]

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======= TRPM7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPM7
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily M member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54822|54822]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QT4|Q96QT4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPM7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPM7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605692|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Essential ion channel and serine/threonine-protein kinase. Divalent cation channel permeable to calcium and magnesium. Has a central role in magnesium ion homeostasis and in the regulation of anoxic neuronal cell death. Involved in TNF- induced necroptosis downstream of MLKL by mediating calcium influx. The kinase activity is essential for the channel function. May be involved in a fundamental process that adjusts plasma membrane divalent cation fluxes according to the metabolic state of the cell. Phosphorylates annexin A1 (ANXA1). {ECO:0000269|PubMed:12887921, ECO:0000269|PubMed:15485879, ECO:0000269|PubMed:24316671}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alpha kinase|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium-dependent cell-matrix adhesion|
|cellular magnesium ion homeostasis|
|magnesium ion homeostasis|
|necroptotic process|
|myosin binding|
|programmed necrotic cell death|
|necrotic cell death|
|calcium channel activity|
|ruffle|
|actomyosin structure organization|
|cell-matrix adhesion|
|protein tetramerization|
|cell-substrate adhesion|
|protein autophosphorylation|
|calcium ion transmembrane transport|
|calcium ion transport|
|actin binding|
|divalent metal ion transport|
|divalent inorganic cation transport|
|protein serine/threonine kinase activity|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|protein complex oligomerization|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|actin filament-based process|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|cell adhesion|
|biological adhesion|
|ion transmembrane transport|
|protein phosphorylation|
|programmed cell death|
|cell death|
|cytoskeleton organization|
|chemical homeostasis|
|transmembrane transport|
|phosphorylation|
|ion transport|
|ATP binding|
|protein-containing complex assembly|
|homeostatic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.77|
|[[:results:exp100|NFN1 1μM R03 exp100]]|1.71|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 208/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|18/28|
|bone|3/26|
|breast|15/33|
|central nervous system|4/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|6/21|
|liver|3/20|
|lung|28/75|
|lymphocyte|6/16|
|ovary|5/26|
|pancreas|11/24|
|peripheral nervous system|2/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1658
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPM7 Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>