TRPV4 [The Human Chemical-Genetic Interaction Map Project]

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======= TRPV4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRPV4
  * **<color #00a2e8>Official Name</color>**: transient receptor potential cation channel subfamily V member 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=59341|59341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9HBA0|Q9HBA0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRPV4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRPV4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605427|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of brown fat cell differentiation|
|signal transduction involved in regulation of aerobic respiration|
|blood vessel endothelial cell delamination|
|osmosensor activity|
|cellular hypotonic salinity response|
|vasopressin secretion|
|positive regulation of macrophage inflammatory protein 1 alpha production|
|positive regulation of chemokine (C-X-C motif) ligand 1 production|
|hypotonic salinity response|
|regulation of chemokine (C-X-C motif) ligand 1 production|
|stretch-activated, cation-selective, calcium channel activity|
|osmosensory signaling pathway|
|cortical microtubule organization|
|positive regulation of microtubule depolymerization|
|delamination|
|positive regulation of chemokine (C-C motif) ligand 5 production|
|regulation of macrophage inflammatory protein 1 alpha production|
|cellular response to salt stress|
|cellular hypotonic response|
|regulation of aerobic respiration|
|hyperosmotic salinity response|
|regulation of chemokine (C-C motif) ligand 5 production|
|hypotonic response|
|positive regulation of monocyte chemotactic protein-1 production|
|positive regulation of vascular permeability|
|diet induced thermogenesis|
|regulation of response to osmotic stress|
|positive regulation of macrophage chemotaxis|
|regulation of brown fat cell differentiation|
|regulation of monocyte chemotactic protein-1 production|
|cation channel activity|
|adaptive thermogenesis|
|positive regulation of macrophage migration|
|positive regulation of protein depolymerization|
|response to salt stress|
|hyperosmotic response|
|ion channel activity|
|regulation of macrophage chemotaxis|
|response to dietary excess|
|cell volume homeostasis|
|regulation of microtubule depolymerization|
|regulation of cellular respiration|
|positive regulation of interleukin-6 secretion|
|microtubule polymerization|
|positive regulation of microtubule polymerization or depolymerization|
|energy homeostasis|
|cellular response to osmotic stress|
|SH2 domain binding|
|regulation of vascular permeability|
|regulation of macrophage migration|
|positive regulation of protein complex disassembly|
|beta-tubulin binding|
|alpha-tubulin binding|
|calcium ion import|
|regulation of granulocyte chemotaxis|
|cartilage development involved in endochondral bone morphogenesis|
|negative regulation of fat cell differentiation|
|regulation of mononuclear cell migration|
|cortical cytoskeleton organization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|cortical actin cytoskeleton|
|calcium channel activity|
|cytoplasmic microtubule organization|
|protein kinase C binding|
|positive regulation of chemokine production|
|peptide hormone secretion|
|adherens junction|
|actin cytoskeleton reorganization|
|multicellular organismal water homeostasis|
|cellular response to heat|
|hormone secretion|
|filopodium|
|endochondral bone morphogenesis|
|water homeostasis|
|response to osmotic stress|
|regulation of chemokine production|
|regulation of microtubule polymerization or depolymerization|
|hormone transport|
|regulation of protein depolymerization|
|protein polymerization|
|positive regulation of leukocyte chemotaxis|
|positive regulation of interleukin-6 production|
|ruffle membrane|
|cell-cell junction assembly|
|response to heat|
|regulation of leukocyte chemotaxis|
|bone morphogenesis|
|regulation of protein complex disassembly|
|regulation of fat cell differentiation|
|positive regulation of leukocyte migration|
|growth cone|
|positive regulation of chemotaxis|
|cell-cell junction organization|
|positive regulation of JNK cascade|
|positive regulation of inflammatory response|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|negative regulation of neuron projection development|
|lipid binding|
|regulation of generation of precursor metabolites and energy|
|positive regulation of stress-activated MAPK cascade|
|positive regulation of stress-activated protein kinase signaling cascade|
|cell junction assembly|
|vascular process in circulatory system|
|signal release|
|cartilage development|
|peptide secretion|
|negative regulation of cell-cell adhesion|
|response to temperature stimulus|
|lamellipodium|
|regulation of cell size|
|negative regulation of cell projection organization|
|glucose homeostasis|
|regulation of JNK cascade|
|carbohydrate homeostasis|
|regulation of microtubule cytoskeleton organization|
|regulation of leukocyte migration|
|positive regulation of supramolecular fiber organization|
|calcium ion transmembrane transport|
|cilium|
|bone development|
|calmodulin binding|
|actin filament binding|
|regulation of cytokine secretion|
|positive regulation of ERK1 and ERK2 cascade|
|response to mechanical stimulus|
|regulation of chemotaxis|
|cell junction organization|
|positive regulation of cytoskeleton organization|
|regulation of microtubule-based process|
|connective tissue development|
|negative regulation of neuron differentiation|
|response to insulin|
|regulation of stress-activated MAPK cascade|
|regulation of stress-activated protein kinase signaling cascade|
|microtubule binding|
|skeletal system morphogenesis|
|actin filament organization|
|calcium ion transport|
|cytoplasmic vesicle|
|actin binding|
|positive regulation of protein secretion|
|negative regulation of cell adhesion|
|positive regulation of cytosolic calcium ion concentration|
|positive regulation of peptide secretion|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|divalent metal ion transport|
|divalent inorganic cation transport|
|negative regulation of nervous system development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|apical plasma membrane|
|multicellular organismal homeostasis|
|regulation of cytosolic calcium ion concentration|
|negative regulation of cell development|
|regulation of inflammatory response|
|regulation of supramolecular fiber organization|
|regulation of cellular component size|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|focal adhesion|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|positive regulation of cytokine production|
|calcium ion homeostasis|
|supramolecular fiber organization|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of protein secretion|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|positive regulation of defense response|
|microtubule cytoskeleton organization|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|actin cytoskeleton organization|
|skeletal system development|
|regulation of neuron projection development|
|regulation of body fluid levels|
|response to nutrient levels|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|actin filament-based process|
|positive regulation of response to external stimulus|
|cation transmembrane transport|
|cell surface|
|positive regulation of organelle organization|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|regulation of neuron differentiation|
|microtubule-based process|
|regulation of cell adhesion|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of protein transport|
|cation homeostasis|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|inorganic ion homeostasis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|regulation of defense response|
|ion homeostasis|
|regulation of secretion|
|regulation of neurogenesis|
|cation transport|
|cellular protein-containing complex assembly|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|ion transmembrane transport|
|animal organ morphogenesis|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|response to organonitrogen compound|
|secretion by cell|
|endoplasmic reticulum|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|export from cell|
|positive regulation of phosphorylation|
|identical protein binding|
|response to nitrogen compound|
|regulation of response to external stimulus|
|cytoskeleton organization|
|chemical homeostasis|
|cell-cell signaling|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of immune system process|
|response to abiotic stimulus|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|transmembrane transport|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|integral component of plasma membrane|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5366
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRPV4 Expression in NALM6 Cells: -4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>