TSPYL5 [The Human Chemical-Genetic Interaction Map Project]

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======= TSPYL5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPYL5
  * **<color #00a2e8>Official Name</color>**: TSPY like 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=85453|85453]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VY4|Q86VY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPYL5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPYL5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614721|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in modulation of cell growth and cellular response to gamma radiation probably via regulation of the Akt signaling pathway. Involved in regulation of p53/TP53. Suppresses p53/TP53 protein levels and promotes its ubiquitination; the function is dependent on USP7 and independent on MDM2. Proposed to displace p53/TP53 from interaction with USP7. {ECO:0000269|PubMed:20079711, ECO:0000269|PubMed:21170034}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to gamma radiation|
|response to gamma radiation|
|cellular response to ionizing radiation|
|positive regulation of protein ubiquitination|
|nucleosome assembly|
|chromatin assembly|
|positive regulation of protein modification by small protein conjugation or removal|
|response to ionizing radiation|
|chromatin assembly or disassembly|
|nucleosome organization|
|positive regulation of protein kinase B signaling|
|cellular response to radiation|
|DNA packaging|
|regulation of protein ubiquitination|
|protein-DNA complex assembly|
|regulation of protein kinase B signaling|
|regulation of protein modification by small protein conjugation or removal|
|protein-DNA complex subunit organization|
|DNA conformation change|
|cellular response to abiotic stimulus|
|cellular response to environmental stimulus|
|response to radiation|
|regulation of growth|
|chromatin organization|
|cellular protein-containing complex assembly|
|positive regulation of cell population proliferation|
|positive regulation of intracellular signal transduction|
|chromosome organization|
|response to abiotic stimulus|
|positive regulation of protein modification process|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.588|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 275/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|17/28|
|bone|11/26|
|breast|14/33|
|central nervous system|16/56|
|cervix|3/4|
|colorectal|7/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|8/21|
|liver|7/20|
|lung|25/75|
|lymphocyte|6/16|
|ovary|12/26|
|pancreas|6/24|
|peripheral nervous system|11/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|5/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5384
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPYL5 Expression in NALM6 Cells: -5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>