TTC26 [The Human Chemical-Genetic Interaction Map Project]

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======= TTC26 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTC26
  * **<color #00a2e8>Official Name</color>**: tetratricopeptide repeat domain 26
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79989|79989]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A0AVF1|A0AVF1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTC26&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTC26|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the intraflagellar transport (IFT) complex B required for transport of proteins in the motile cilium. Required for transport of specific ciliary cargo proteins related to motility, while it is neither required for IFT complex B assembly or motion nor for cilium assembly. Required for efficient coupling between the accumulation of GLI3 at the ciliary tip and its dissociation from SUFU. {ECO:0000250|UniProtKB:Q8BS45}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|manchette assembly|
|intraciliary anterograde transport|
|intraciliary transport particle B binding|
|intraciliary transport particle B|
|ciliary base|
|intraciliary transport involved in cilium assembly|
|ciliary tip|
|protein localization to cilium|
|intraciliary transport|
|axoneme assembly|
|microtubule-based protein transport|
|protein transport along microtubule|
|smoothened signaling pathway|
|microtubule bundle formation|
|motile cilium|
|ciliary basal body|
|spermatid development|
|transport along microtubule|
|spermatid differentiation|
|cytoskeleton-dependent intracellular transport|
|microtubule-based transport|
|cilium|
|germ cell development|
|protein-containing complex localization|
|microtubule-based movement|
|cilium assembly|
|cellular process involved in reproduction in multicellular organism|
|cilium organization|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|microtubule cytoskeleton organization|
|centrosome|
|spermatogenesis|
|male gamete generation|
|developmental process involved in reproduction|
|microtubule-based process|
|gamete generation|
|protein localization to organelle|
|organelle assembly|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|intracellular protein transport|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|reproductive process|
|reproduction|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.85|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.76|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.85|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.91|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|2.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13081
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTC26 Expression in NALM6 Cells: 4.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>