TTC27 [The Human Chemical-Genetic Interaction Map Project]

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======= TTC27 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTC27
  * **<color #00a2e8>Official Name</color>**: tetratricopeptide repeat domain 27
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55622|55622]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P3X3|Q6P3X3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTC27&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTC27|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular component|
|molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp116|AICAR 240μM R03 exp116]]|-2.25|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.18|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-2|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.95|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.95|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.84|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.82|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.73|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-1.72|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-1.7|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 699/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|27/28|
|blood|28/28|
|bone|24/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|14/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|20/21|
|liver|19/20|
|lung|69/75|
|lymphocyte|16/16|
|ovary|23/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|8/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|26/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 400
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTC27 Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>