TUBB8 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBB8 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBB8
  * **<color #00a2e8>Official Name</color>**: tubulin beta 8 class VIII
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=347688|347688]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q3ZCM7|Q3ZCM7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBB8&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBB8|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616768|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene represents the primary beta-tubulin subunit of oocytes and the early embryo. Defects in this gene, which is primate-specific, are a cause of oocyte maturation defect 2 and infertility. [provided by RefSeq, Mar 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity). TUBB8 has a key role in meiotic spindle assembly and oocyte maturation (PubMed:26789871). {ECO:0000250, ECO:0000269|PubMed:26789871}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin|
|Tubulin C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|spindle assembly involved in female meiosis|
|spindle assembly involved in meiosis|
|meiotic spindle|
|meiotic spindle organization|
|oocyte maturation|
|female meiotic nuclear division|
|oocyte development|
|oocyte differentiation|
|oogenesis|
|spindle assembly|
|structural constituent of cytoskeleton|
|female gamete generation|
|anatomical structure maturation|
|meiotic nuclear division|
|spindle organization|
|cell maturation|
|meiotic cell cycle process|
|meiotic cell cycle|
|developmental maturation|
|germ cell development|
|nuclear division|
|organelle fission|
|microtubule|
|GTPase activity|
|cellular process involved in reproduction in multicellular organism|
|GTP binding|
|microtubule cytoskeleton organization|
|developmental process involved in reproduction|
|microtubule-based process|
|mitotic cell cycle|
|gamete generation|
|organelle assembly|
|molecular function|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.8|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.76|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1889
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBB8 Expression in NALM6 Cells: 0.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>