TUBE1 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBE1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBE1
  * **<color #00a2e8>Official Name</color>**: tubulin epsilon 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51175|51175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJT0|Q9UJT0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBE1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBE1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607345|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin C|
|Tubulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pericentriolar material|
|centrosome cycle|
|microtubule organizing center organization|
|structural constituent of cytoskeleton|
|microtubule|
|GTPase activity|
|GTP binding|
|microtubule cytoskeleton organization|
|microtubule-based process|
|mitotic cell cycle|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.9|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|1.72|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.8|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.8|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.81|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.83|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.84|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.94|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.96|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.34|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|3.41|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|4.03|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|4.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c14orf80|C14orf80]]|0.718|
|[[:human genes:t:tubd1|TUBD1]]|0.715|
|[[:human genes:c:c16orf59|C16orf59]]|0.681|
|[[:human genes:c:cep120|CEP120]]|0.545|
|[[:human genes:c:c2cd3|C2CD3]]|0.523|
|[[:human genes:p:pidd|PIDD]]|0.512|
|[[:human genes:o:odf2|ODF2]]|0.505|
|[[:human genes:c:cradd|CRADD]]|0.502|
|[[:human genes:c:casp2|CASP2]]|0.494|
|[[:human genes:p:pmvk|PMVK]]|0.493|
|[[:human genes:c:cep44|CEP44]]|0.49|
|[[:human genes:p:pibf1|PIBF1]]|0.487|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.469|
|[[:human genes:u:urm1|URM1]]|0.461|
|[[:human genes:s:sclt1|SCLT1]]|0.458|
|[[:human genes:p:ptar1|PTAR1]]|0.458|
|[[:human genes:a:ankrd26|ANKRD26]]|0.457|
|[[:human genes:n:n6amt1|N6AMT1]]|0.454|
|[[:human genes:p:ppcdc|PPCDC]]|0.452|
|[[:human genes:c:c15orf41|C15orf41]]|0.45|
|[[:human genes:c:ccdc41|CCDC41]]|0.448|
|[[:human genes:e:elp3|ELP3]]|0.43|
|[[:human genes:b:bub3|BUB3]]|0.429|
|[[:human genes:r:rpia|RPIA]]|0.421|
|[[:human genes:t:thg1l|THG1L]]|0.421|
|[[:human genes:s:srp14|SRP14]]|0.418|
|[[:human genes:o:ofd1|OFD1]]|0.416|
|[[:human genes:p:ppp6c|PPP6C]]|0.413|
|[[:human genes:n:nin|NIN]]|0.411|
|[[:human genes:g:gemin6|GEMIN6]]|0.41|
|[[:human genes:g:gemin8|GEMIN8]]|0.407|
|[[:human genes:a:atxn10|ATXN10]]|0.402|
|[[:human genes:t:trmt61a|TRMT61A]]|0.402|
|[[:human genes:r:rttn|RTTN]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 23/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|1/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1407
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBE1 Expression in NALM6 Cells: 5.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>