TUBG2 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBG2
  * **<color #00a2e8>Official Name</color>**: tubulin gamma 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27175|27175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRH3|Q9NRH3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605785|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin C|
|Misat Myo SegII|
|Tubulin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|meiotic spindle organization|
|gamma-tubulin complex|
|microtubule nucleation|
|pericentriolar material|
|microtubule polymerization|
|spindle microtubule|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule|
|cytoplasmic microtubule organization|
|mitotic spindle organization|
|protein polymerization|
|structural constituent of cytoskeleton|
|microtubule cytoskeleton organization involved in mitosis|
|mitotic sister chromatid segregation|
|spindle|
|sister chromatid segregation|
|mitotic nuclear division|
|microtubule cytoskeleton|
|spindle organization|
|meiotic cell cycle process|
|structural molecule activity|
|nuclear chromosome segregation|
|meiotic cell cycle|
|chromosome segregation|
|nuclear division|
|organelle fission|
|microtubule|
|GTPase activity|
|GTP binding|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|mitotic cell cycle process|
|microtubule-based process|
|mitotic cell cycle|
|cellular protein-containing complex assembly|
|cell cycle process|
|chromosome organization|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5636
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBG2 Expression in NALM6 Cells: 1.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>