TUBGCP3 [The Human Chemical-Genetic Interaction Map Project]

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======= TUBGCP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBGCP3
  * **<color #00a2e8>Official Name</color>**: tubulin gamma complex associated protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10426|10426]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96CW5|Q96CW5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBGCP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBGCP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617818|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Spc97 Spc98|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|gamma-tubulin small complex|
|polar microtubule|
|equatorial microtubule organizing center|
|microtubule nucleation by interphase microtubule organizing center|
|microtubule nucleation by microtubule organizing center|
|microtubule minus-end binding|
|gamma-tubulin complex|
|microtubule nucleation|
|gamma-tubulin binding|
|microtubule polymerization|
|microtubule polymerization or depolymerization|
|cytoplasmic microtubule organization|
|protein polymerization|
|spindle assembly|
|structural constituent of cytoskeleton|
|spindle|
|single fertilization|
|centriole|
|spindle organization|
|fertilization|
|structural molecule activity|
|meiotic cell cycle|
|supramolecular fiber organization|
|microtubule cytoskeleton organization|
|centrosome|
|microtubule-based process|
|mitotic cell cycle|
|organelle assembly|
|sexual reproduction|
|cellular protein-containing complex assembly|
|multi-organism reproductive process|
|cell cycle process|
|cytoskeleton organization|
|cell cycle|
|reproductive process|
|reproduction|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-2.31|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.71|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.73|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|1.78|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.418|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 344/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|13/28|
|bone|13/26|
|breast|18/33|
|central nervous system|28/56|
|cervix|2/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|10/21|
|liver|12/20|
|lung|41/75|
|lymphocyte|4/16|
|ovary|16/26|
|pancreas|8/24|
|peripheral nervous system|9/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|6/24|
|soft tissue|7/9|
|thyroid|2/2|
|upper aerodigestive|5/22|
|urinary tract|6/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1859
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBGCP3 Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>