TULP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TULP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TULP1
  * **<color #00a2e8>Official Name</color>**: TUB like protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7287|7287]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00294|O00294]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TULP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TULP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602280|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the tubby-like gene family (TULPs). Members of this family have been identified in plants, vertebrates, and invertebrates. TULP proteins share a conserved C-terminal region of approximately 200 amino acid residues. The protein encoded by this gene is thought to play a role in the physiology of photoreceptors. Mutations in this gene are associated with recessive juvenile retinitis pigmentosa and Leber congenital amaurosis-15. [provided by RefSeq, Nov 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells (By similarity). Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. {ECO:0000250, ECO:0000269|PubMed:16303976, ECO:0000269|PubMed:19837063}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tub|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to photoreceptor outer segment|
|protein localization to non-motile cilium|
|detection of light stimulus involved in sensory perception|
|detection of light stimulus involved in visual perception|
|eye photoreceptor cell development|
|photoreceptor cell maintenance|
|eye photoreceptor cell differentiation|
|protein localization to cilium|
|photoreceptor cell development|
|detection of visible light|
|photoreceptor inner segment|
|axon terminus|
|photoreceptor cell differentiation|
|detection of light stimulus|
|photoreceptor outer segment|
|positive regulation of phagocytosis|
|retina homeostasis|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of phagocytosis|
|cell projection|
|dendrite development|
|phagocytosis, recognition|
|detection of external stimulus|
|detection of abiotic stimulus|
|retina development in camera-type eye|
|eye morphogenesis|
|tissue homeostasis|
|cilium|
|actin filament binding|
|visual perception|
|sensory perception of light stimulus|
|cell recognition|
|sensory organ morphogenesis|
|synapse|
|response to light stimulus|
|camera-type eye development|
|multicellular organismal homeostasis|
|phagocytosis|
|anatomical structure homeostasis|
|eye development|
|visual system development|
|sensory system development|
|response to radiation|
|detection of stimulus involved in sensory perception|
|sensory organ development|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|neuron projection development|
|import into cell|
|detection of stimulus|
|protein localization to organelle|
|neuron development|
|animal organ morphogenesis|
|sensory perception|
|positive regulation of transport|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|nervous system process|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|homeostatic process|
|cell development|
|regulation of transport|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.33 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TULP1 Expression in NALM6 Cells: -0.33'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>