TXNDC17 [The Human Chemical-Genetic Interaction Map Project]

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======= TXNDC17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNDC17
  * **<color #00a2e8>Official Name</color>**: thioredoxin domain containing 17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84817|84817]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRA2|Q9BRA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNDC17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNDC17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616967|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF-alpha signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF953|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein-disulfide reductase activity|
|peroxidase activity|
|cellular oxidant detoxification|
|cellular detoxification|
|tumor necrosis factor-mediated signaling pathway|
|detoxification|
|cellular response to toxic substance|
|cellular response to tumor necrosis factor|
|response to tumor necrosis factor|
|response to toxic substance|
|cytokine-mediated signaling pathway|
|oxidation-reduction process|
|cellular response to cytokine stimulus|
|response to cytokine|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.38|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.73|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.73|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.77|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.95|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.18|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.27|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.34|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|2.37|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|2.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.442|
|[[:human genes:w:wdr24|WDR24]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.73 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNDC17 Expression in NALM6 Cells: 4.73'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>