TXNRD1 [The Human Chemical-Genetic Interaction Map Project]

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======= TXNRD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNRD1
  * **<color #00a2e8>Official Name</color>**: thioredoxin reductase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7296|7296]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16881|Q16881]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNRD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNRD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601112|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms, including a glutaredoxin-containing isoform that is predominantly expressed in testis. [provided by RefSeq, May 2017]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pyr redox|
|Pyr redox 2|
|Pyr redox dim|
|FAD binding 2|
|Glutaredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|selenium compound metabolic process|
|thioredoxin-disulfide reductase activity|
|protein disulfide oxidoreductase activity|
|nucleobase-containing small molecule interconversion|
|flavin adenine dinucleotide binding|
|mesoderm formation|
|mesoderm morphogenesis|
|electron transfer activity|
|cell redox homeostasis|
|cellular oxidant detoxification|
|cellular detoxification|
|formation of primary germ layer|
|mesoderm development|
|detoxification|
|fibrillar center|
|gastrulation|
|electron transport chain|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|response to oxidative stress|
|regulation of lipid metabolic process|
|generation of precursor metabolites and energy|
|response to toxic substance|
|nucleobase-containing small molecule metabolic process|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|oxidation-reduction process|
|embryo development|
|mitochondrion|
|homeostatic process|
|cellular response to stress|
|small molecule metabolic process|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2.37|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.35|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.13|
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.87|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.78|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.75|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.81|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.86|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.86|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.98|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|2.3|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.36|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.53|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.547|
|[[:human genes:p:pmm2|PMM2]]|0.532|
|[[:human genes:a:alg1|ALG1]]|0.508|
|[[:human genes:h:hars|HARS]]|0.486|
|[[:human genes:t:triap1|TRIAP1]]|0.485|
|[[:human genes:r:rnmt|RNMT]]|0.473|
|[[:human genes:r:rpp21|RPP21]]|0.473|
|[[:human genes:a:atxn10|ATXN10]]|0.467|
|[[:human genes:l:lsm10|LSM10]]|0.466|
|[[:human genes:m:med16|MED16]]|0.464|
|[[:human genes:t:ttc4|TTC4]]|0.463|
|[[:human genes:v:vezt|VEZT]]|0.46|
|[[:human genes:n:nae1|NAE1]]|0.451|
|[[:human genes:d:dpagt1|DPAGT1]]|0.446|
|[[:human genes:p:pelo|PELO]]|0.445|
|[[:human genes:r:rptor|RPTOR]]|0.445|
|[[:human genes:e:eny2|ENY2]]|0.438|
|[[:human genes:u:uap1|UAP1]]|0.428|
|[[:human genes:t:trmt5|TRMT5]]|0.426|
|[[:human genes:d:dr1|DR1]]|0.425|
|[[:human genes:r:rpia|RPIA]]|0.425|
|[[:human genes:a:atp5h|ATP5H]]|0.419|
|[[:human genes:f:fh|FH]]|0.414|
|[[:human genes:t:tle4|TLE4]]|0.413|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.412|
|[[:human genes:h:hspd1|HSPD1]]|0.411|
|[[:human genes:a:alg2|ALG2]]|0.411|
|[[:human genes:t:tprkb|TPRKB]]|0.409|
|[[:human genes:t:tsen54|TSEN54]]|0.409|
|[[:human genes:d:ddx39a|DDX39A]]|0.408|
|[[:human genes:c:ccdc101|CCDC101]]|0.407|
|[[:human genes:w:wdr24|WDR24]]|0.407|
|[[:human genes:a:aars|AARS]]|0.406|
|[[:human genes:u:uhrf1|UHRF1]]|0.405|
|[[:human genes:g:gfpt1|GFPT1]]|0.403|
|[[:human genes:a:abcf1|ABCF1]]|0.4|
|[[:human genes:t:tmem41b|TMEM41B]]|0.4|
|[[:human genes:s:sdha|SDHA]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 191/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|2/28|
|bone|12/26|
|breast|6/33|
|central nervous system|25/56|
|cervix|3/4|
|colorectal|1/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|5/21|
|liver|5/20|
|lung|18/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|7/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|11/22|
|urinary tract|8/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNRD1 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>