TYRP1 [The Human Chemical-Genetic Interaction Map Project]

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======= TYRP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TYRP1
  * **<color #00a2e8>Official Name</color>**: tyrosinase related protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7306|7306]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17643|P17643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TYRP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TYRP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/115501|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the oxidation of 5,6-dihydroxyindole-2- carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions (PubMed:28661582). May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458). Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity). {ECO:0000250|UniProtKB:P07147, ECO:0000269|PubMed:28661582, ECO:0000305|PubMed:16704458, ECO:0000305|PubMed:22556244, ECO:0000305|PubMed:23504663}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tyrosinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetoacetic acid metabolic process|
|monophenol monooxygenase activity|
|intracellular vesicle|
|positive regulation of melanin biosynthetic process|
|positive regulation of secondary metabolite biosynthetic process|
|regulation of melanin biosynthetic process|
|regulation of secondary metabolite biosynthetic process|
|ketone body metabolic process|
|melanin biosynthetic process|
|regulation of secondary metabolic process|
|melanosome membrane|
|melanin metabolic process|
|short-chain fatty acid metabolic process|
|secondary metabolite biosynthetic process|
|melanocyte differentiation|
|melanosome organization|
|pigment granule organization|
|pigment cell differentiation|
|clathrin-coated endocytic vesicle membrane|
|phenol-containing compound biosynthetic process|
|developmental pigmentation|
|cellular pigmentation|
|pigment biosynthetic process|
|secondary metabolic process|
|pigment metabolic process|
|phenol-containing compound metabolic process|
|pigmentation|
|melanosome|
|oxidoreductase activity|
|fatty acid derivative metabolic process|
|organic hydroxy compound biosynthetic process|
|endosome membrane|
|vesicle organization|
|fatty acid metabolic process|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|protein heterodimerization activity|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|protein homodimerization activity|
|carboxylic acid metabolic process|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|organic acid metabolic process|
|aromatic compound biosynthetic process|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|small molecule metabolic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TYRP1 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>