U2SURP [The Human Chemical-Genetic Interaction Map Project]

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======= U2SURP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: U2SURP
  * **<color #00a2e8>Official Name</color>**: U2 snRNP associated SURP domain containing
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23350|23350]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15042|O15042]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=U2SURP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20U2SURP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cwf21|
|Surp|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.01|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.87|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-1.85|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.81|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.78|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.77|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-1.76|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.73|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.72|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-1.71|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.71|
|[[:results:exp261|ABT-702 5μM R06 exp261]]|1.75|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.85|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.9|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.24|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.34|
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|2.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 413/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|21/28|
|bone|15/26|
|breast|21/33|
|central nervous system|30/56|
|cervix|0/4|
|colorectal|8/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|7/16|
|kidney|11/21|
|liver|9/20|
|lung|44/75|
|lymphocyte|13/16|
|ovary|16/26|
|pancreas|14/24|
|peripheral nervous system|14/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|17/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|9/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 939
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='U2SURP Expression in NALM6 Cells: 8.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>