UBA2 [The Human Chemical-Genetic Interaction Map Project]

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======= UBA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBA2
  * **<color #00a2e8>Official Name</color>**: ubiquitin like modifier activating enzyme 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10054|10054]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UBT2|Q9UBT2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBACT|
|ThiF|
|UBA e1 thiolCys|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO activating enzyme activity|
|SUMO activating enzyme complex|
|small protein activating enzyme binding|
|ubiquitin-like protein conjugating enzyme binding|
|SUMO binding|
|enzyme activator activity|
|transferase activity|
|protein sumoylation|
|magnesium ion binding|
|peptidyl-lysine modification|
|transcription factor binding|
|protein heterodimerization activity|
|protein modification by small protein conjugation|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|positive regulation of catalytic activity|
|ATP binding|
|positive regulation of molecular function|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-1.77|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.73|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.73|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|4.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sae1|SAE1]]|0.475|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 678/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|24/28|
|bone|25/26|
|breast|31/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|15/16|
|kidney|21/21|
|liver|16/20|
|lung|68/75|
|lymphocyte|16/16|
|ovary|24/26|
|pancreas|22/24|
|peripheral nervous system|15/16|
|plasma cell|13/15|
|prostate|1/1|
|skin|21/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|20/22|
|urinary tract|28/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1385
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBA2 Expression in NALM6 Cells: 7.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>