UBE2D3 [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2D3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2D3
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 D3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7323|7323]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61077|P61077]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2D3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2D3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602963|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML- NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction. {ECO:0000269|PubMed:10329681, ECO:0000269|PubMed:11743028, ECO:0000269|PubMed:12646252, ECO:0000269|PubMed:15247280, ECO:0000269|PubMed:15280377, ECO:0000269|PubMed:15496420, ECO:0000269|PubMed:16628214, ECO:0000269|PubMed:18284575, ECO:0000269|PubMed:18508924, ECO:0000269|PubMed:18515077, ECO:0000269|PubMed:18948756, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20347421, ECO:0000269|PubMed:21532592}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRIF-dependent toll-like receptor signaling pathway|
|protein K11-linked ubiquitination|
|MyD88-independent toll-like receptor signaling pathway|
|positive regulation of protein targeting to mitochondrion|
|ubiquitin conjugating enzyme activity|
|regulation of protein targeting to mitochondrion|
|protein K48-linked ubiquitination|
|positive regulation of establishment of protein localization to mitochondrion|
|protein monoubiquitination|
|protein autoubiquitination|
|establishment of protein localization to peroxisome|
|protein localization to peroxisome|
|protein targeting to peroxisome|
|peroxisomal transport|
|regulation of establishment of protein localization to mitochondrion|
|peroxisome organization|
|regulation of protein targeting|
|BMP signaling pathway|
|toll-like receptor signaling pathway|
|ubiquitin ligase complex|
|response to BMP|
|cellular response to BMP stimulus|
|positive regulation of mitochondrion organization|
|pattern recognition receptor signaling pathway|
|positive regulation of intracellular protein transport|
|regulation of mitochondrion organization|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of intracellular transport|
|endosome membrane|
|regulation of intracellular protein transport|
|innate immune response-activating signal transduction|
|ubiquitin-protein transferase activity|
|activation of innate immune response|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|positive regulation of cellular protein localization|
|positive regulation of innate immune response|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|protein targeting|
|positive regulation of response to biotic stimulus|
|positive regulation of protein transport|
|establishment of protein localization to organelle|
|regulation of innate immune response|
|positive regulation of establishment of protein localization|
|positive regulation of defense response|
|cellular response to growth factor stimulus|
|DNA repair|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|activation of immune response|
|protein catabolic process|
|protein ubiquitination|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|regulation of peptide transport|
|DNA metabolic process|
|regulation of establishment of protein localization|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|cellular response to DNA damage stimulus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|intracellular protein transport|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of immune system process|
|cellular response to stress|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-3.02|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.91|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|-2.46|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.44|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.41|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.31|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-2.23|
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.19|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|-2.19|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.17|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-2.16|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.16|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.15|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.15|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-2.13|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-2.12|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.09|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.08|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-2.07|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-2.06|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-1.99|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-1.93|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.92|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-1.92|
|[[:results:exp302|35°C R06 exp302]]|-1.88|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.86|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-1.84|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.83|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.81|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|-1.8|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-1.78|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.78|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.75|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.84|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.9|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:otub1|OTUB1]]|0.484|
|[[:human genes:u:ube2d2|UBE2D2]]|0.424|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 196/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|14/28|
|bone|6/26|
|breast|11/33|
|central nervous system|13/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|7/21|
|liver|1/20|
|lung|20/75|
|lymphocyte|7/16|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|3/9|
|thyroid|1/2|
|upper aerodigestive|7/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3406
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2D3 Expression in NALM6 Cells: 7.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>