UBE2J1 [The Human Chemical-Genetic Interaction Map Project]

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======= UBE2J1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2J1
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 J1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51465|51465]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y385|Q9Y385]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2J1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2J1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616175|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of retrograde protein transport, ER to cytosol|
|negative regulation of protein exit from endoplasmic reticulum|
|regulation of retrograde protein transport, ER to cytosol|
|negative regulation of ERAD pathway|
|regulation of protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|regulation of tumor necrosis factor biosynthetic process|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|ubiquitin conjugating enzyme activity|
|negative regulation of intracellular protein transport|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of intracellular transport|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|protein N-linked glycosylation|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|regulation of cytokine biosynthetic process|
|negative regulation of cellular protein localization|
|negative regulation of protein catabolic process|
|regulation of tumor necrosis factor production|
|spermatid development|
|regulation of tumor necrosis factor superfamily cytokine production|
|spermatid differentiation|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|negative regulation of establishment of protein localization|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|germ cell development|
|response to endoplasmic reticulum stress|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|ubiquitin protein ligase binding|
|negative regulation of catabolic process|
|glycoprotein biosynthetic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|cellular process involved in reproduction in multicellular organism|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|spermatogenesis|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|developmental process involved in reproduction|
|protein catabolic process|
|protein ubiquitination|
|gamete generation|
|regulation of cytokine production|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|regulation of cellular catabolic process|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|endoplasmic reticulum membrane|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|multi-organism reproductive process|
|response to organonitrogen compound|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|proteolysis|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|ATP binding|
|negative regulation of response to stimulus|
|cell development|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.76|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|-2.65|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.52|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.17|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.06|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-2.05|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.97|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.97|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.89|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|-1.86|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.85|
|[[:results:exp453|B02 10μM R08 exp453]]|-1.83|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.81|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.79|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.72|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.71|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.72|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.74|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|1.79|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.9|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.95|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.97|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|1.99|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|2.04|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.06|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.11|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.11|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|2.18|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:d:dnajc3|DNAJC3]]|0.665|
|[[:human genes:m:manf|MANF]]|0.619|
|[[:human genes:d:derl2|DERL2]]|0.602|
|[[:human genes:u:ube2g2|UBE2G2]]|0.582|
|[[:human genes:a:alg5|ALG5]]|0.556|
|[[:human genes:u:ufm1|UFM1]]|0.554|
|[[:human genes:d:dnajb11|DNAJB11]]|0.547|
|[[:human genes:p:pmm2|PMM2]]|0.527|
|[[:human genes:c:c1orf27|C1orf27]]|0.526|
|[[:human genes:u:ufc1|UFC1]]|0.523|
|[[:human genes:d:derl1|DERL1]]|0.505|
|[[:human genes:u:uba5|UBA5]]|0.501|
|[[:human genes:u:ufsp2|UFSP2]]|0.483|
|[[:human genes:a:alg9|ALG9]]|0.481|
|[[:human genes:h:hars|HARS]]|0.48|
|[[:human genes:e:eny2|ENY2]]|0.479|
|[[:human genes:x:xpo6|XPO6]]|0.477|
|[[:human genes:t:tmem41b|TMEM41B]]|0.477|
|[[:human genes:t:tmed10|TMED10]]|0.476|
|[[:human genes:s:sec62|SEC62]]|0.475|
|[[:human genes:r:rpe|RPE]]|0.47|
|[[:human genes:t:taz|TAZ]]|0.468|
|[[:human genes:a:aup1|AUP1]]|0.462|
|[[:human genes:d:dpagt1|DPAGT1]]|0.462|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.461|
|[[:human genes:a:alg1|ALG1]]|0.46|
|[[:human genes:v:vmp1|VMP1]]|0.456|
|[[:human genes:r:rptor|RPTOR]]|0.444|
|[[:human genes:o:opa1|OPA1]]|0.442|
|[[:human genes:d:dad1|DAD1]]|0.441|
|[[:human genes:u:ube2k|UBE2K]]|0.441|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.437|
|[[:human genes:t:trmt5|TRMT5]]|0.433|
|[[:human genes:a:alg6|ALG6]]|0.433|
|[[:human genes:f:faf2|FAF2]]|0.431|
|[[:human genes:s:sec63|SEC63]]|0.431|
|[[:human genes:r:rnmt|RNMT]]|0.43|
|[[:human genes:r:romo1|ROMO1]]|0.428|
|[[:human genes:t:triap1|TRIAP1]]|0.425|
|[[:human genes:h:hspd1|HSPD1]]|0.423|
|[[:human genes:c:ccdc101|CCDC101]]|0.423|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.421|
|[[:human genes:u:ufl1|UFL1]]|0.42|
|[[:human genes:s:stt3a|STT3A]]|0.419|
|[[:human genes:g:gmppb|GMPPB]]|0.419|
|[[:human genes:o:os9|OS9]]|0.418|
|[[:human genes:o:otud5|OTUD5]]|0.416|
|[[:human genes:c:crls1|CRLS1]]|0.415|
|[[:human genes:b:bap1|BAP1]]|0.412|
|[[:human genes:p:plaa|PLAA]]|0.411|
|[[:human genes:a:alg2|ALG2]]|0.411|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.408|
|[[:human genes:r:rps6kb1|RPS6KB1]]|0.407|
|[[:human genes:o:ost4|OST4]]|0.406|
|[[:human genes:a:atp5j|ATP5J]]|0.406|
|[[:human genes:k:kcmf1|KCMF1]]|0.406|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.405|
|[[:human genes:r:rad1|RAD1]]|0.405|
|[[:human genes:m:mllt1|MLLT1]]|0.404|
|[[:human genes:c:cbfb|CBFB]]|0.403|
|[[:human genes:t:thoc6|THOC6]]|0.402|
|[[:human genes:s:srp14|SRP14]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3517
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2J1 Expression in NALM6 Cells: 7.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>